Identification of possible cigarette smoke constituents responsible for muscle catabolism

The age-related loss of muscle mass and strength also known as sarcopenia is significantly influenced by life style factors such as physical inactivity and impaired nutrition. Cigarette smoking is another life style habit that has been shown to be associated with sarcopenia and to affect skeletal mu...

Full description

Saved in:
Bibliographic Details
Published in:Journal of muscle research and cell motility 2012-08, Vol.33 (3-4), p.199-208
Main Authors: Rom, Oren, Kaisari, Sharon, Aizenbud, Dror, Reznick, Abraham Z.
Format: Article
Language:English
Subjects:
Aerosols
Animal Anatomy
Biomedical and Life Sciences
Biomedicine
Cell Biology
EMC2012 Special Issue - Review
Histology
Humans
Life Sciences
Morphology
Muscle, Skeletal - metabolism
Proteomics
Sarcopenia - etiology
Sarcopenia - metabolism
Smoking - adverse effects
Smoking - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The age-related loss of muscle mass and strength also known as sarcopenia is significantly influenced by life style factors such as physical inactivity and impaired nutrition. Cigarette smoking is another life style habit that has been shown to be associated with sarcopenia and to affect skeletal muscle. Even today, smoking is still prevalent worldwide and is probably the most significant source of toxic chemicals exposure to humans. Cigarette smoke (CS) is a complex aerosol consisting of thousands of various constituents including reactive oxygen and nitrogen free radicals, toxic aldehydes and more. Previous epidemiological studies have identified tobacco smoking as a risk factor for sarcopenia. Clinical, in vivo and in vitro studies have revealed CS-induced skeletal muscle damage due to impaired muscle metabolism, increased inflammation and oxidative stress, over-expression of atrophy related genes and activation of various intracellular signaling pathways. This review aims to discuss and identify the components of CS that may promote catabolism of skeletal muscle.
ISSN:0142-4319
1573-2657
DOI:10.1007/s10974-012-9299-4