The influence of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine on citrate content, activities of aconitase and citrate synthase in rats exposed to cerebral ischemia-reperfusion

The effect of guanidine derivatives on citrate content and activity of aconitate hydratase and citrate synthase have been investigated in rats with cerebral ischemia-reperfusion. Administration of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine resulted in changes...

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Published in:Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2012-04, Vol.6 (2), p.171-176
Main Authors: Sukhoveeva, O. V., Popova, T. N., Makeeva, A. V., Iskusnykh, I. Yu
Format: Article
Language:English
Subjects:
Aconitate hydratase
Biochemistry
Bioorganic Chemistry
Brain
Chemistry
Chemistry and Materials Science
Enzymes
Ischemia
Medicinal Chemistry
Oxidative stress
Rodents
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Summary:The effect of guanidine derivatives on citrate content and activity of aconitate hydratase and citrate synthase have been investigated in rats with cerebral ischemia-reperfusion. Administration of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine resulted in changes of specific activities of aconitase and citrate synthase towards control values. Under these conditions the citrate level considerably decreased versus rats with untreated ishemia-reperfusion. Administration of these biguanidines compounds also decreased the degree of DNA fragmentation, which was markedly increased in rats with ischemia-reperfusion. The dose-dependent effects of guanidine derivatives suggest that they exhibit not only antioxidant but also prooxidant effects.
ISSN:1990-7508
1990-7516
DOI:10.1134/S1990750812020138