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Middle cerebral artery blood flow velocity in response to lower body positive pressure
Summary Lower body positive pressure (LBPP) has been used in the treatment of haemorrhagic shock and in offsetting g‐force induced fluid shifts. However, the middle cerebral artery blood flow velocity (MCAv) response to supine LBPP is unknown. Fifteen healthy volunteers (mean ± SD: age, 26 ± 5 year;...
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| Published in: | Clinical physiology and functional imaging 2013-11, Vol.33 (6), p.483-488 |
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| container_end_page | 488 |
| container_issue | 6 |
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| container_title | Clinical physiology and functional imaging |
| container_volume | 33 |
| creator | Perry, Blake G. Schlader, Zachary J. Raman, Aaron Cochrane, Darryl J. Lucas, Samuel J. E. Mündel, Toby |
| description | Summary
Lower body positive pressure (LBPP) has been used in the treatment of haemorrhagic shock and in offsetting g‐force induced fluid shifts. However, the middle cerebral artery blood flow velocity (MCAv) response to supine LBPP is unknown. Fifteen healthy volunteers (mean ± SD: age, 26 ± 5 year; body mass, 79 ± 10 kg; height, 174 ± 9 cm) completed 5 minutes of 20 and 40 mm Hg LBPP, in a randomized order, separated by 5 minutes rest (baseline). Beat‐to‐beat MCAv and blood pressure, partial pressure of end‐tidal carbon dioxide (PETCO2) and heart rate were recorded and presented as the change from the preceding baseline. All measures were similar between baseline periods (all P>0·30). Mean arterial pressure (MAP) increased by 7 ± 6 (8 ± 7%) and 13 ± 7 mm Hg (19 ± 11%) from baseline during 20 and 40 mm Hg (P |
| doi_str_mv | 10.1111/cpf.12046 |
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Lower body positive pressure (LBPP) has been used in the treatment of haemorrhagic shock and in offsetting g‐force induced fluid shifts. However, the middle cerebral artery blood flow velocity (MCAv) response to supine LBPP is unknown. Fifteen healthy volunteers (mean ± SD: age, 26 ± 5 year; body mass, 79 ± 10 kg; height, 174 ± 9 cm) completed 5 minutes of 20 and 40 mm Hg LBPP, in a randomized order, separated by 5 minutes rest (baseline). Beat‐to‐beat MCAv and blood pressure, partial pressure of end‐tidal carbon dioxide (PETCO2) and heart rate were recorded and presented as the change from the preceding baseline. All measures were similar between baseline periods (all P>0·30). Mean arterial pressure (MAP) increased by 7 ± 6 (8 ± 7%) and 13 ± 7 mm Hg (19 ± 11%) from baseline during 20 and 40 mm Hg (P<0·01), respectively. The greater MAP increase at 40 mm Hg (P<0·01 versus 20 mm Hg) was mediated via a greater increase in total peripheral resistance (P<0·01), with heart rate, cardiac output (Model flow) and PETCO2 remaining unchanged (all P>0·05) throughout. MCAv increased from baseline by 3 ± 4 cm s−1 (5 ± 5%) during 20 mm Hg (P = 0·003), whilst no change (P = 0·18) was observed during 40 mm Hg. Our results indicate a divergent response, in that 20 mm Hg LBPP‐induced modest increases in both MCAv and MAP, yet no change in MCAv was observed at the higher LBPP of 40 mm Hg despite a further increase in MAP.</description><identifier>ISSN: 1475-0961</identifier><identifier>EISSN: 1475-097X</identifier><identifier>DOI: 10.1111/cpf.12046</identifier><identifier>PMID: 23701382</identifier><identifier>CODEN: CPFICA</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adaptation, Physiological ; Adult ; Age ; arterial blood pressure ; Arterial Pressure ; Blood Flow Velocity ; cerebral autoregulation ; cerebral blood flow ; cerebral haemodynamics ; Cerebrovascular Circulation ; Female ; Humans ; Lower Body Negative Pressure ; Male ; Middle Cerebral Artery - diagnostic imaging ; Middle Cerebral Artery - physiology ; Supine Position ; sympathetic nervous system ; Time Factors ; Ultrasonography, Doppler, Pulsed ; Ultrasonography, Doppler, Transcranial ; Vascular Resistance ; Young Adult</subject><ispartof>Clinical physiology and functional imaging, 2013-11, Vol.33 (6), p.483-488</ispartof><rights>2013 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd</rights><rights>2013 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2013 Scandinavian Society of Clinical Physiology and Nuclear Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4246-14d6dfbb5559b7063f2b2a0e9916560af4ab22d43c7412ef5a4cd3cba756a25a3</citedby><cites>FETCH-LOGICAL-c4246-14d6dfbb5559b7063f2b2a0e9916560af4ab22d43c7412ef5a4cd3cba756a25a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23701382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perry, Blake G.</creatorcontrib><creatorcontrib>Schlader, Zachary J.</creatorcontrib><creatorcontrib>Raman, Aaron</creatorcontrib><creatorcontrib>Cochrane, Darryl J.</creatorcontrib><creatorcontrib>Lucas, Samuel J. E.</creatorcontrib><creatorcontrib>Mündel, Toby</creatorcontrib><title>Middle cerebral artery blood flow velocity in response to lower body positive pressure</title><title>Clinical physiology and functional imaging</title><addtitle>Clin Physiol Funct Imaging</addtitle><description>Summary
Lower body positive pressure (LBPP) has been used in the treatment of haemorrhagic shock and in offsetting g‐force induced fluid shifts. However, the middle cerebral artery blood flow velocity (MCAv) response to supine LBPP is unknown. Fifteen healthy volunteers (mean ± SD: age, 26 ± 5 year; body mass, 79 ± 10 kg; height, 174 ± 9 cm) completed 5 minutes of 20 and 40 mm Hg LBPP, in a randomized order, separated by 5 minutes rest (baseline). Beat‐to‐beat MCAv and blood pressure, partial pressure of end‐tidal carbon dioxide (PETCO2) and heart rate were recorded and presented as the change from the preceding baseline. All measures were similar between baseline periods (all P>0·30). Mean arterial pressure (MAP) increased by 7 ± 6 (8 ± 7%) and 13 ± 7 mm Hg (19 ± 11%) from baseline during 20 and 40 mm Hg (P<0·01), respectively. The greater MAP increase at 40 mm Hg (P<0·01 versus 20 mm Hg) was mediated via a greater increase in total peripheral resistance (P<0·01), with heart rate, cardiac output (Model flow) and PETCO2 remaining unchanged (all P>0·05) throughout. MCAv increased from baseline by 3 ± 4 cm s−1 (5 ± 5%) during 20 mm Hg (P = 0·003), whilst no change (P = 0·18) was observed during 40 mm Hg. Our results indicate a divergent response, in that 20 mm Hg LBPP‐induced modest increases in both MCAv and MAP, yet no change in MCAv was observed at the higher LBPP of 40 mm Hg despite a further increase in MAP.</description><subject>Adaptation, Physiological</subject><subject>Adult</subject><subject>Age</subject><subject>arterial blood pressure</subject><subject>Arterial Pressure</subject><subject>Blood Flow Velocity</subject><subject>cerebral autoregulation</subject><subject>cerebral blood flow</subject><subject>cerebral haemodynamics</subject><subject>Cerebrovascular Circulation</subject><subject>Female</subject><subject>Humans</subject><subject>Lower Body Negative Pressure</subject><subject>Male</subject><subject>Middle Cerebral Artery - diagnostic imaging</subject><subject>Middle Cerebral Artery - physiology</subject><subject>Supine Position</subject><subject>sympathetic nervous system</subject><subject>Time Factors</subject><subject>Ultrasonography, Doppler, Pulsed</subject><subject>Ultrasonography, Doppler, Transcranial</subject><subject>Vascular Resistance</subject><subject>Young Adult</subject><issn>1475-0961</issn><issn>1475-097X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqN0U1rFDEYB_Agiq3Vg19AAl70MG3es3PUxVZLuyr4dgt5eQZSZzdjMtN2vn1jt92DIDSXBPJ7_iT8EXpJySGt68gP3SFlRKhHaJ8KLRvS6l-Pd2dF99CzUi4IoZoL_RTtMa4J5Qu2j36cxxB6wB4yuGx7bPMIecauTyngrk9X-BL65OM447jBGcqQNgXwmHC9g4xdCjMeUoljvAQ8VFCmDM_Rk872BV7c7Qfo-_GHb8uPzdnnk0_Ld2eNF0yohoqgQueclLJ1mijeMccsgbalSipiO2EdY0FwrwVl0EkrfODeWS2VZdLyA_Rmmzvk9GeCMpp1LB763m4gTcVQ0apFy7liD6CC85Zrvaj09T_0Ik15Uz9SFV-0mmsmq3q7VT6nUjJ0ZshxbfNsKDF_ezG1F3PbS7Wv7hInt4awk_dFVHC0BVexh_n_SWb55fg-stlOxDLC9W7C5t9G1QdK83N1Yk5XK_2ekq9mxW8AvGylbQ</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Perry, Blake G.</creator><creator>Schlader, Zachary J.</creator><creator>Raman, Aaron</creator><creator>Cochrane, Darryl J.</creator><creator>Lucas, Samuel J. E.</creator><creator>Mündel, Toby</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TS</scope><scope>7U5</scope><scope>8FD</scope><scope>K9.</scope><scope>L7M</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201311</creationdate><title>Middle cerebral artery blood flow velocity in response to lower body positive pressure</title><author>Perry, Blake G. ; Schlader, Zachary J. ; Raman, Aaron ; Cochrane, Darryl J. ; Lucas, Samuel J. E. ; Mündel, Toby</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4246-14d6dfbb5559b7063f2b2a0e9916560af4ab22d43c7412ef5a4cd3cba756a25a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adaptation, Physiological</topic><topic>Adult</topic><topic>Age</topic><topic>arterial blood pressure</topic><topic>Arterial Pressure</topic><topic>Blood Flow Velocity</topic><topic>cerebral autoregulation</topic><topic>cerebral blood flow</topic><topic>cerebral haemodynamics</topic><topic>Cerebrovascular Circulation</topic><topic>Female</topic><topic>Humans</topic><topic>Lower Body Negative Pressure</topic><topic>Male</topic><topic>Middle Cerebral Artery - diagnostic imaging</topic><topic>Middle Cerebral Artery - physiology</topic><topic>Supine Position</topic><topic>sympathetic nervous system</topic><topic>Time Factors</topic><topic>Ultrasonography, Doppler, Pulsed</topic><topic>Ultrasonography, Doppler, Transcranial</topic><topic>Vascular Resistance</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perry, Blake G.</creatorcontrib><creatorcontrib>Schlader, Zachary J.</creatorcontrib><creatorcontrib>Raman, Aaron</creatorcontrib><creatorcontrib>Cochrane, Darryl J.</creatorcontrib><creatorcontrib>Lucas, Samuel J. E.</creatorcontrib><creatorcontrib>Mündel, Toby</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Clinical physiology and functional imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perry, Blake G.</au><au>Schlader, Zachary J.</au><au>Raman, Aaron</au><au>Cochrane, Darryl J.</au><au>Lucas, Samuel J. E.</au><au>Mündel, Toby</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Middle cerebral artery blood flow velocity in response to lower body positive pressure</atitle><jtitle>Clinical physiology and functional imaging</jtitle><addtitle>Clin Physiol Funct Imaging</addtitle><date>2013-11</date><risdate>2013</risdate><volume>33</volume><issue>6</issue><spage>483</spage><epage>488</epage><pages>483-488</pages><issn>1475-0961</issn><eissn>1475-097X</eissn><coden>CPFICA</coden><abstract>Summary
Lower body positive pressure (LBPP) has been used in the treatment of haemorrhagic shock and in offsetting g‐force induced fluid shifts. However, the middle cerebral artery blood flow velocity (MCAv) response to supine LBPP is unknown. Fifteen healthy volunteers (mean ± SD: age, 26 ± 5 year; body mass, 79 ± 10 kg; height, 174 ± 9 cm) completed 5 minutes of 20 and 40 mm Hg LBPP, in a randomized order, separated by 5 minutes rest (baseline). Beat‐to‐beat MCAv and blood pressure, partial pressure of end‐tidal carbon dioxide (PETCO2) and heart rate were recorded and presented as the change from the preceding baseline. All measures were similar between baseline periods (all P>0·30). Mean arterial pressure (MAP) increased by 7 ± 6 (8 ± 7%) and 13 ± 7 mm Hg (19 ± 11%) from baseline during 20 and 40 mm Hg (P<0·01), respectively. The greater MAP increase at 40 mm Hg (P<0·01 versus 20 mm Hg) was mediated via a greater increase in total peripheral resistance (P<0·01), with heart rate, cardiac output (Model flow) and PETCO2 remaining unchanged (all P>0·05) throughout. MCAv increased from baseline by 3 ± 4 cm s−1 (5 ± 5%) during 20 mm Hg (P = 0·003), whilst no change (P = 0·18) was observed during 40 mm Hg. Our results indicate a divergent response, in that 20 mm Hg LBPP‐induced modest increases in both MCAv and MAP, yet no change in MCAv was observed at the higher LBPP of 40 mm Hg despite a further increase in MAP.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23701382</pmid><doi>10.1111/cpf.12046</doi><tpages>6</tpages></addata></record> |
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| subjects | Adaptation, Physiological Adult Age arterial blood pressure Arterial Pressure Blood Flow Velocity cerebral autoregulation cerebral blood flow cerebral haemodynamics Cerebrovascular Circulation Female Humans Lower Body Negative Pressure Male Middle Cerebral Artery - diagnostic imaging Middle Cerebral Artery - physiology Supine Position sympathetic nervous system Time Factors Ultrasonography, Doppler, Pulsed Ultrasonography, Doppler, Transcranial Vascular Resistance Young Adult |
| title | Middle cerebral artery blood flow velocity in response to lower body positive pressure |
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