Intraoperative Cryoprecipitate Transfusion and Its Association with the Incidence of Biliary Complications after Liver Transplantation-A Retrospective Cohort Study. e60727

Background Cryoprecipitate is largely used for acquired hypofibrinogenemia in the setting of massive hemorrhage in liver transplantation (LT). However, the influence of intraoperative cryoprecipitate transfusion on biliary complications (BC) after LT has not been studied in detail. Study Design and...

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Bibliographic Details
Published in:PloS one 2013-05, Vol.8 (5)
Main Authors: Liu, Shuang, Fan, Junwei, Wang, Xiaoliang, Gong, Zijun, Wang, Shuyun, Huang, Li, Xing, Tonghai, Li, Tao, Peng, Zhihai, Sun, Xing
Format: Article
Language:English
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Summary:Background Cryoprecipitate is largely used for acquired hypofibrinogenemia in the setting of massive hemorrhage in liver transplantation (LT). However, the influence of intraoperative cryoprecipitate transfusion on biliary complications (BC) after LT has not been studied in detail. Study Design and Methods In a series of 356 adult patients who received their first LT, the causes of BC were retrospectively studied by multivariate logistic regression analysis. The clinical relationship between intraoperative cryoprecipitate transfusion and BC occurrence was studied through a retrospective cohort study in patients. All patients received follow-ups for one year, and, during the follow-up period, the time of BC occurrence and liver biopsies were recorded. Results Intraoperative cryoprecipitate transfusion (RR = 3.46, 95% CI [1.72-6.97], P8 h (RR = 4.24, 95% CI [2.28-7.92], P
ISSN:1932-6203
DOI:10.1371/journal.pone.0060727