A systematic review of studies assessing the association between adherence to smoking cessation medication and treatment success

Aims Lack of adherence to smoking cessation medication regimens is assumed to play a significant role in limiting their effectiveness. This study aimed to assess evidence for this assumption. Methods A systematic search was conducted, supplemented by expert consultation, of papers reporting on rando...

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Bibliographic Details
Published in:Addiction (Abingdon, England) England), 2014-01, Vol.109 (1), p.35-43
Main Authors: Raupach, Tobias, Brown, Jamie, Herbec, Aleksandra, Brose, Leonie, West, Robert
Format: Article
Language:English
Subjects:
Addictive behaviors
Adherence
Adult and adolescent clinical studies
Associations
Benzazepines - therapeutic use
Biological and medical sciences
bupropion
Bupropion - therapeutic use
cessation
Clinical outcomes
compliance
Consumption
Data analysis
Decision-making
Desintoxication. Drug withdrawal
Dopamine Uptake Inhibitors - therapeutic use
Humans
Medical sciences
Medical treatment
medication
Medication Adherence
Nicotine
nicotine replacement therapy
Nicotinic Agonists - therapeutic use
Observation
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychotherapy
Quinoxalines - therapeutic use
quitting
Regulation
Smoking
Smoking - drug therapy
Smoking cessation
Smoking Cessation - methods
Studies
Success
Systematic review
Tobacco smoking
Tobacco, tobacco smoking
Toxicology
Treatment Outcome
Treatments
Varenicline
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Summary:Aims Lack of adherence to smoking cessation medication regimens is assumed to play a significant role in limiting their effectiveness. This study aimed to assess evidence for this assumption. Methods A systematic search was conducted, supplemented by expert consultation, of papers reporting on randomized trials and observational studies examining the association between adherence to cessation medication and the success of quit attempts. To rule out reverse causality, only studies where adherence was assessed prior to relapse were included. Five studies met the inclusion criteria and results were extracted independently by two researchers. Heterogeneity between studies precluded a pooled analysis of the data. Results Studies varied widely with regard to both the definition of adherence and outcome measures. The included studies only addressed adherence to nicotine replacement therapy. One study of lozenge use found that the amount of medication used between 1 and 2 weeks after the quit date predicted abstinence at 6 weeks [adjusted odds ratio (OR) for ‘high’ versus ‘low’ lozenge use 1.25; 95% confidence interval (CI) = 1.05–1.50; P 
ISSN:0965-2140
1360-0443
DOI:10.1111/add.12319