The role of TNF-α G-308A promoter polymorphism in glycemic control in Type 2 diabetes patients

• Published in: Journal of endocrinological investigation 2014-02, Vol.37 (2), p.113-118
• Main Authors: Al-Azzam, S. I., Khabour, O. F., Alzoubi, K. H., Ghanma, M. W., Alhasan, A. Y.
• Format: Article
• Language: English
• Subjects: Aged; Blood Glucose - metabolism; Cross-Sectional Studies; Diabetes Complications - blood; Diabetes Complications - genetics; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - therapy; Endocrinology; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; Original Article; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Promoter Regions, Genetic - genetics; Tumor Necrosis Factor-alpha - genetics
• ISSN: 1720-8386; 1720-8386
• DOI: 10.1007/s40618-013-0002-4

Background TNF - α polymorphisms were shown to be associated with insulin resistance and diabetes development and complications. Aim To investigate the association between glycemic control in Type 2 diabetes patients and TNF - α G-308A single nucleotide polymorphism (SNP). Methods This was a cross-sectional observational study, where diabetes patients from both genders (170 male and 185 female) were enrolled in the study. Patients were divided into two groups: good glycemic control ( n  = 158) and poor glycemic control ( n  = 197). Genotyping of TNF - α G-308A SNP was carried out using restriction fragment length polymorphisms-polymerase chain reaction. Results The results showed that TNF - α G-308A SNP is strongly associated with glycemic control in type 2 diabetes patients. Patients with the AA and AG genotypes had better glycemic control than those with GG genotype ( P