Wollastonite toxicity: an update

Abstract This review updates earlier work addressing the epidemiology and toxicity of wollastonite. Earlier chronic animal bioassay and human mortality data were inadequate (IARC term) or negative and no new studies of these types have been published. Wollastonite has been determined to have low bio...

Full description

Saved in:
Bibliographic Details
Published in:Inhalation toxicology 2014-02, Vol.26 (2), p.95-112
Main Authors: Maxim, L. Daniel, Niebo, Ron, Utell, Mark J., McConnell, E. E., LaRosa, Salvatore, Segrave, Alan M.
Format: Article
Language:English
Subjects:
Air Pollutants - toxicity
Animals
Bioceramics
biocompatibility
biopersistence
Calcium Compounds - toxicity
epidemiology
health surveillance
Humans
Lung Diseases - chemically induced
occupational exposure
Silicates - toxicity
toxicity
wollastonite
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract This review updates earlier work addressing the epidemiology and toxicity of wollastonite. Earlier chronic animal bioassay and human mortality data were inadequate (IARC term) or negative and no new studies of these types have been published. Wollastonite has been determined to have low biopersistence in both in vivo and in vitro studies, which probably accounts for its relative lack of toxicity. Earlier morbidity studies of mining/mineral processing facilities in Finland and New York State indicated that exposure to wollastonite might result in pleural plaques (Finland) or decrements in certain measures of lung function (New York). More recent analysis of data from an ongoing health surveillance program at one facility (New York) indicates that there are no pleural plaques or interstitial lung disease or decrements in lung function among never smokers or former smokers occupationally exposed to wollastonite. This result probably reflects continued reduction in exposures as part of an ongoing product stewardship program at this facility and suggests that wollastonite has relatively low toxicity as currently managed.
ISSN:0895-8378
1091-7691
DOI:10.3109/08958378.2013.857372