Sevelamer Hydrochloride Dose-Dependent Increase in Prevalence of Severe Acidosis in Hemodialysis Patients: Analysis of Nationwide Statistical Survey in Japan

• Published in: Therapeutic apheresis and dialysis 2014-02, Vol.18 (1), p.37-43
• Main Authors: Oka, Yoshinari, Miyazaki, Masashi, Matsuda, Hiroaki, Takatsu, Shigeko, Katsube, Ryouichi, Mori, Toshiko, Takehara, Kiyoto, Umeda, Yuzo, Uno, Futoshi
• Format: Article
• Language: English
• Subjects: Acidosis - chemically induced; Acidosis - epidemiology; Aged; Bicarbonates - blood; Chelating Agents - administration & dosage; Chelating Agents - adverse effects; Data Collection; Dialysis; Dose-Response Relationship, Drug; Drug Monitoring - methods; Female; Humans; Japan; Logistic Models; Male; Metabolic acidosis; Middle Aged; Polyamines - administration & dosage; Polyamines - adverse effects; Prevalence; Prognosis; Renal Dialysis; Sevelamer; Sevelamer hydrochloride; Severity of Illness Index
• ISSN: 1744-9979; 1744-9987
• DOI: 10.1111/1744-9987.12052

Metabolic acidosis has a negative impact on prognosis of dialysis patients. The aim of this study was to determine the prevalence of severe metabolic acidosis in dialysis patients treated with sevelamer hydrochloride. In 2004, a nationwide survey (101 516 dialysis patients) was conducted by the Japanese Society for Dialysis Therapy. We analyzed 32 686 dialysis patients whose bicarbonate levels were measured in the survey. Sevelamer hydrochloride was prescribed to 9231 dialysis patients while 23 455 dialysis patients were not prescribed sevelamer hydrochloride. In the present study, we defined severe acidosis as bicarbonate