Contribution of comorbidities and grade of bone marrow fibrosis to the prognosis of survival in patients with primary myelofibrosis

The widely used current International Prognostic Scoring System (IPSS) for primary myelofibrosis (PMF) is based on clinical parameters. The objective of this study was to identify additional prognostic factors at the time of diagnosis, which could have an impact on the future treatment of patients w...

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Published in:Medical oncology (Northwood, London, England) London, England), 2014-03, Vol.31 (3), p.869-869, Article 869
Main Authors: Lekovic, Danijela, Gotic, Mirjana, Perunicic-Jovanovic, Maja, Vidovic, Ana, Bogdanovic, Andrija, Jankovic, Gradimir, Cokic, Vladan, Milic, Natasa
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bone Marrow Diseases - epidemiology
Bone Marrow Diseases - mortality
Bone Marrow Diseases - pathology
Comorbidity
Female
Fibrosis - epidemiology
Fibrosis - mortality
Fibrosis - pathology
Follow-Up Studies
Hematology
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Grading
Oncology
Original Paper
Pathology
Primary Myelofibrosis - epidemiology
Primary Myelofibrosis - mortality
Primary Myelofibrosis - pathology
Prognosis
Retrospective Studies
Serbia - epidemiology
Survival Rate
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Summary:The widely used current International Prognostic Scoring System (IPSS) for primary myelofibrosis (PMF) is based on clinical parameters. The objective of this study was to identify additional prognostic factors at the time of diagnosis, which could have an impact on the future treatment of patients with PMF. We conducted a study of 131 consecutive PMF patients with median follow-up of 44 months. Data on baseline demographics, clinical and laboratory parameters, IPSS, grade of bone marrow fibrosis (MF), as well as influence of concomitant comorbidities were analyzed in terms of survival. Comorbidity was assessed using the Adult Comorbidity Evaluation-27 (ACE-27) score and the hematopoietic cell transplantation comorbidity index. An improved prognostic model of survival was obtained by deploying the MF and ACE-27 to the IPSS. A multivariable regression analyses confirmed the statistical significance of IPSS ( P   1 ( P  = 0.001, HR 2.694, 95 % CI 1.466–4.951) and ACE-27 ( P  
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-014-0869-8