Clinical significance of the appearance of abnormal protein band in patients with multiple myeloma

Multiple myeloma (MM) is characterized by clonal expansion of malignant bone marrow cells producing a unique monoclonal immunoglobulin. The appearance of abnormal protein band (APB) in MM has been reported during follow-up. We aimed to evaluate the clinical characteristics and outcomes of patients w...

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Bibliographic Details
Published in:Annals of hematology 2014-03, Vol.93 (3), p.463-469
Main Authors: Jo, Jae-Cheol, Yoon, Dok Hyun, Kim, Shin, Lee, Kyoungmin, Kang, Eun Hee, Jang, Seongsoo, Park, Chan-Jeoung, Chi, Hyun-Sook, Huh, Jooryung, Park, Chan-Sik, Suh, Cheolwon
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bone Marrow Cells - pathology
Cohort Studies
Female
Follow-Up Studies
Hematology
Humans
Hypergammaglobulinemia - etiology
Immunoglobulin Class Switching
Male
Medicine
Medicine & Public Health
Middle Aged
Multiple Myeloma - blood
Multiple Myeloma - diagnosis
Multiple Myeloma - physiopathology
Multiple Myeloma - therapy
Oligoclonal Bands - analysis
Oncology
Original Article
Plasma Cells - pathology
Prognosis
Retrospective Studies
Stem Cell Transplantation
Survival Analysis
Transplantation, Autologous
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Summary:Multiple myeloma (MM) is characterized by clonal expansion of malignant bone marrow cells producing a unique monoclonal immunoglobulin. The appearance of abnormal protein band (APB) in MM has been reported during follow-up. We aimed to evaluate the clinical characteristics and outcomes of patients with APB in a single center cohort. A total of 377 consecutive MM patients were treated at the Asan Medical Center between January 2002 and December 2012. We compared clinical characteristics and survival outcome between those with and without APB. Of the 377 patients, 34 (9 %) experienced APB. They comprised 18.2 % (27/148) of patients treated with autologous stem cell transplantation (ASCT) and 3.1 % (7/229) of those not receiving ASCT. APB occurred after a median of 7.9 months (range, 2.2–95.7 months) from diagnosis. Immunoglobulin isotypes at diagnosis were as follows: IgG ( n  = 10), IgA ( n  = 8), IgD ( n  = 5), free κ ( n  = 4), and free λ ( n  = 7). Nine patients experienced a second APB. With a median follow-up of 54.1 months, the median overall survival (OS) has not been reached in patients with APB and was 38.3 months in patients without ( P  
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-013-1890-2