NMDA and AMPA receptors in the anterior cingulate cortex mediates visceral pain in visceral hypersensitivity rats

• Published in: Cellular immunology 2014-02, Vol.287 (2), p.86-90
• Main Authors: Zhou, Lin, Huang, Junjing, Gao, Jun, Zhang, Guanpo, Jiang, Jinjin
• Format: Article
• Language: English
• Subjects: Administration, Rectal; Animals; Animals, Newborn; Anterior cingulate cortex; Cells, Cultured; Disease Models, Animal; Gyrus Cinguli - metabolism; Humans; Hypersensitivity - metabolism; Mustard Plant; N-methyl-d-aspartate; Neuronal Plasticity; Plant Oils - administration & dosage; Rats; Rats, Sprague-Dawley; Receptors, AMPA - metabolism; Receptors, N-Methyl-D-Aspartate - metabolism; Signal Transduction; Visceral hypersensitivity; Visceral Pain - metabolism; α-Amino-3-hydroxy-5-methyl-4-isox-azolepropionic-acid
• ISSN: 0008-8749; 1090-2163
• DOI: 10.1016/j.cellimm.2013.12.001

•NMDA receptors played an important role on the process of visceral hypersensitivity.•AMPA receptors were widely distributed in the limbic system and the hypothalamus.•GluR2 induced by inflammation participated in maintenance of synaptic excitability. Several studies have shown that N-methyl-d-aspartate (NMDA)-receptor activation in anterior cingulate cortex (ACC) neurons plays critical roles in modulating visceral pain responses in visceral hypersensitivity (VH) rats. However, there are few reports about the expressions of NMDA and α-amino-3-hydroxy-5-methyl-4-isox-azolepropionic-acid (AMPA) receptor subtypes in ACC of VH model rats at different time points. The current study was undertaken to investigate NR2A, NR2B and GluR2 expressions in ACC of VH rats that were induced by administration with 5% mustard oil. Our results indicated that NR2B, but not NR2A, was highly expressed in VH model group on day 15, 22, and 36 compared with normal group (p