Relationships between oral infections and blood glucose concentrations or HbA1c levels in normal and diabetic rats

Aim To measure glycosylated haemoglobin (HbA1c) in a diabetic model as a means of investigating apical periodontitis and periodontal disease for their effects on both blood glucose concentrations and long‐term glycaemic control. Methodology Wistar rats (n = 80) were assigned to one of eight groups (...

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Bibliographic Details
Published in:International endodontic journal 2014-03, Vol.47 (3), p.228-237
Main Authors: Cintra, L. T. A., Samuel, R. O., Facundo, A. C. S., Prieto, A. K. C., Sumida, D. H., Bomfim, S. R. M., Souza, J. C., Dezan-Júnior, E., Gomes-Filho, J. E.
Format: Article
Language:English
Subjects:
Alveolar Bone Loss - blood
Animals
blood glucose
Blood Glucose - analysis
Chromatography, Ion Exchange
Dentistry
diabetes
Diabetes Mellitus, Experimental - blood
Glycated Hemoglobin A - analysis
HbA1c levels
Male
Maxilla
oral infections
Periodontal Diseases - blood
Rats
Rats, Wistar
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Summary:Aim To measure glycosylated haemoglobin (HbA1c) in a diabetic model as a means of investigating apical periodontitis and periodontal disease for their effects on both blood glucose concentrations and long‐term glycaemic control. Methodology Wistar rats (n = 80) were assigned to one of eight groups (10 animals/group): control (G1), apical periodontitis (G2), periodontal disease (G3), apical periodontitis and periodontal disease (G4), diabetic (G5), diabetic with apical periodontitis (G6), diabetic with periodontal disease (G7) and diabetic with apical periodontitis and periodontal disease (G8). A diabetic state was induced with streptozotocin. Apical periodontitis was induced by dental exposure to the oral environment. Periodontal disease was induced by periodontal ligature. Blood glucose concentrations were measured at 0, 6, 30 and 60 days. After euthanization, rat maxillae were excised and processed for histopathology and for measurement of HbA1c levels by ion exchange chromatography. Data were tabulated and subject to statistical analysis (P 
ISSN:0143-2885
1365-2591
DOI:10.1111/iej.12136