Association of Cardiotrophin-1 With Myocardial Fibrosis in Hypertensive Patients With Heart Failure

Cardiotrophin-1 has been shown to be profibrogenic in experimental models. The aim of this study was to analyze whether cardiotrophin-1 is associated with left ventricular end-diastolic stress and myocardial fibrosis in hypertensive patients with heart failure. Endomyocardial biopsies from patients...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2014-03, Vol.63 (3), p.483-489
Main Authors: López, Begoña, González, Arantxa, Querejeta, Ramón, Larman, Mariano, Rábago, Gregorio, Díez, Javier
Format: Article
Language:English
Subjects:
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiomyopathies - etiology
Cardiomyopathies - genetics
Cardiomyopathies - metabolism
Cytokines - biosynthesis
Cytokines - genetics
Disease Progression
Enzyme-Linked Immunosorbent Assay
Female
Fibroblasts - metabolism
Fibroblasts - pathology
Fibrosis - etiology
Fibrosis - metabolism
Fibrosis - pathology
Gene Expression Regulation
Heart
Heart Failure - complications
Heart Failure - genetics
Heart Failure - metabolism
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Hypertension - complications
Hypertension - genetics
Hypertension - metabolism
Immunohistochemistry
Male
Medical sciences
Middle Aged
Myocardium - metabolism
Myocardium - pathology
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - pathology
Real-Time Polymerase Chain Reaction
RNA, Messenger - genetics
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Summary:Cardiotrophin-1 has been shown to be profibrogenic in experimental models. The aim of this study was to analyze whether cardiotrophin-1 is associated with left ventricular end-diastolic stress and myocardial fibrosis in hypertensive patients with heart failure. Endomyocardial biopsies from patients (n=31) and necropsies from 7 control subjects were studied. Myocardial cardiotrophin-1 protein and mRNA and the fraction of myocardial volume occupied by collagen were increased in patients compared with controls (P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.113.02654