Measurement of absolute regional lung air volumes from near-field x-ray speckles

Propagation-based phase contrast x-ray (PBX) imaging yields high contrast images of the lung where airways that overlap in projection coherently scatter the x-rays, giving rise to a speckled intensity due to interference effects. Our previous works have shown that total and regional changes in lung...

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Bibliographic Details
Published in:Optics express 2013-11, Vol.21 (23), p.27905-27923
Main Authors: Leong, Andrew F T, Paganin, David M, Hooper, Stuart B, Siew, Melissa L, Kitchen, Marcus J
Format: Article
Language:English
Subjects:
Algorithms
Calibration
Humans
Lung - diagnostic imaging
Phantoms, Imaging
Tomography, X-Ray Computed - methods
X-Rays
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Summary:Propagation-based phase contrast x-ray (PBX) imaging yields high contrast images of the lung where airways that overlap in projection coherently scatter the x-rays, giving rise to a speckled intensity due to interference effects. Our previous works have shown that total and regional changes in lung air volumes can be accurately measured from two-dimensional (2D) absorption or phase contrast images when the subject is immersed in a water-filled container. In this paper we demonstrate how the phase contrast speckle patterns can be used to directly measure absolute regional lung air volumes from 2D PBX images without the need for a water-filled container. We justify this technique analytically and via simulation using the transport-of-intensity equation and calibrate the technique using our existing methods for measuring lung air volume. Finally, we show the full capabilities of this technique for measuring regional differences in lung aeration.
ISSN:1094-4087
1094-4087
DOI:10.1364/OE.21.027905