The correlation between preputial blood flow and microvessel density in distal hypospadias: A prospective clinical study

Abstract Objective A prospective clinical study was designed to investigate the correlation between preputial blood flow (BF) and microvessel density (MVD). Patients and methods A total of 44 children were included in the study. The hypospadias group consisted of 16 children undergoing distal hyposp...

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Bibliographic Details
Published in:Journal of pediatric urology 2014-02, Vol.10 (1), p.103-106
Main Authors: Ceyhan, Levent, Cagri Savas, Mustafa, Baspinar, Sirin, Duman, Levent, Büyükyavuz, Behcet Ilker
Format: Article
Language:English
Subjects:
Blood flow
Child
Child, Preschool
Foreskin - blood supply
Humans
Hypospadias
Hypospadias - metabolism
Hypospadias - physiopathology
Immunohistochemistry
Laser Doppler flowmetry
Male
Microvessel density
Microvessels - metabolism
Pediatrics
Penis - blood supply
Prepuce
Prospective Studies
Regional Blood Flow
Urology
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Summary:Abstract Objective A prospective clinical study was designed to investigate the correlation between preputial blood flow (BF) and microvessel density (MVD). Patients and methods A total of 44 children were included in the study. The hypospadias group consisted of 16 children undergoing distal hypospadias repair, and the control group consisted of 28 age-matched healthy children undergoing circumcision. BFs were measured using a laser Doppler flowmeter on the most distal part of the dorsal prepuces, and then the tissue samples were harvested from the same location. They were immunostained with an antibody against CD31 in order to assay MVD. The statistical analyses were carried out using Student's t test and Pearson's correlation analysis. Results The preputial MVD was found to be significantly decreased in the patients with hypospadias compared with the healthy children (33.95 ± 9.79 vs. 48.25 ± 10.08; p   0.05). Conclusions We found no correlation between the preputial MVD and BF in the present study. This result suggests that reduced preputial MVD does not have any influence on BF in distal hypospadias.
ISSN:1477-5131
1873-4898
DOI:10.1016/j.jpurol.2013.07.003