Is leptin a predictive factor in patients with lung cancer?

The aim of this study was to evaluate the expression and clinical significance of leptin in lung cancer. 126 patients with lung cancer ranged from 30 to 83years of age were studied. Serum leptin levels were determined by ELISA. The mRNA and protein levels of leptin in normal and lung cancer tissues...

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Bibliographic Details
Published in:Clinical biochemistry 2014-02, Vol.47 (3), p.230-232
Main Authors: Song, Cui-Hong, Liao, Jie, Deng, Zi-Hui, Zhang, Jin-Ying, Xue, Hui, Li, Yong-Ming, Liang, Chen, Han, Ming, Zhang, Kai, Yan, Guang-Tao
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarker
Female
Humans
Leptin
Leptin - blood
Lung cancer
Lung Neoplasms - blood
Male
Middle Aged
Neoplasm Proteins - blood
Predictive Value of Tests
RNA, Messenger - blood
RNA, Neoplasm - blood
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Summary:The aim of this study was to evaluate the expression and clinical significance of leptin in lung cancer. 126 patients with lung cancer ranged from 30 to 83years of age were studied. Serum leptin levels were determined by ELISA. The mRNA and protein levels of leptin in normal and lung cancer tissues were measured by RT-PCR and immunohistochemistry. The relationships between leptin levels and clinicopathological factors were evaluated by Wilcoxon rank sum or Kruskal–Wallis H test. Serum leptin levels in lung cancer patients were significantly higher compared to those in controls and leptin expression in lung cancer tissue was markedly increased than that in normal lung tissue (both P
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2013.12.003