Expression of phosphatase of regenerating liver-3 (PRL-3) in endometrioid cancer and lymph nodes metastases

• Published in: Advances in medical sciences 2013-12, Vol.58 (2), p.221-226
• Main Authors: Guzińska-Ustymowicz, K, Kiśluk, J, Terlikowski, SJ, Pryczynicz, A, Niewiarowska, K, Ustymowicz, M, Hawryluk, M, Południewski, M, Kemona, A
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal - pharmacology; Carcinoma, Endometrioid - enzymology; Carcinoma, Endometrioid - secondary; endometrial cancer; Endometrial Neoplasms - enzymology; Endometrial Neoplasms - pathology; Female; Humans; Immunohistochemistry; Lymph Nodes - enzymology; Lymph Nodes - pathology; Lymphatic Metastasis; Middle Aged; Neoplasm Proteins - immunology; Neoplasm Proteins - metabolism; Neoplasm Staging; PRL-3; Prognosis; Protein Tyrosine Phosphatases - immunology; Protein Tyrosine Phosphatases - metabolism; PTP4A3
• ISSN: 1896-1126; 1898-4002
• DOI: 10.2478/v10039-012-0079-6

We identify the expression of PRL-3 in primary endometrioid endometrial cancer and metastases in relation to the clinicopathological characteristics. The study involved 30 patients with type I endometrial cancer. Twelve of them were diagnosed with metastases in various localization of abdomen. The PRL-3 expression was evaluated on the basis of immunohistochemistry results by the use of monoclonal antibody anti-PRL3 clone 3B6. The intensity of PRL-3 expression in correlation with tumor stage was statistically significant (p = 0.024). The strongest reaction was noted in cases classified as a 1a and 1b stage defined by FIGO. The strength of PRL-3 expression is significantly associated with the degree of histological tumor grade (p = 0.035). The strong expression of PRL-3 in the primary tumor that was significantly correlated with the grade and clinical stage suggest that PTP4A3 participates in the process of endometrial carcinogenesis.