Fluorescent conjugate of sLex-selective bisboronic acid for imaging application

Carbohydrate-based biomarkers such as sialyl Lewis X are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed a boronolectin-fluorophore conjugate, which was able to selectively label and image xenograft (sc) tumor. This represents the very first e...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2013-12, Vol.23 (23), p.6307-6309
Main Authors: Chu, Yong, Wang, Danzhu, Wang, Ke, Liu, Zhiren (Luis), Weston, Brent, Wang, Binghe
Format: Article
Language:English
Subjects:
Biomarker
biomarkers
Boronolectin
Cancer
chemistry
fluorescence
image analysis
Optical imaging
Xenograft tumer
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Summary:Carbohydrate-based biomarkers such as sialyl Lewis X are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed a boronolectin-fluorophore conjugate, which was able to selectively label and image xenograft (sc) tumor. This represents the very first example that a small molecule capable of recognizing a carbohydrate biomarker was used for optical imaging application.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2013.09.063