Noncanonical Wnt Comes of Age in Hematopoietic Stem Cells

Understanding molecular mechanisms of aging is crucial in efforts to reverse it. In a recent issue of Nature, Florian et al. (2013) report that increasing levels of noncanonical Wnt signaling accompany hematopoietic stem cell (HSC) aging, which can be modulated to functionally rejuvenate HSCs.

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Bibliographic Details
Published in:Cell stem cell 2013-12, Vol.13 (6), p.642-643
Main Authors: Verovskaya, Evgenia, de Haan, Gerald
Format: Article
Language:English
Subjects:
Animals
Cellular Senescence
Female
Hematopoietic Stem Cells - cytology
Male
Wnt Signaling Pathway
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Summary:Understanding molecular mechanisms of aging is crucial in efforts to reverse it. In a recent issue of Nature, Florian et al. (2013) report that increasing levels of noncanonical Wnt signaling accompany hematopoietic stem cell (HSC) aging, which can be modulated to functionally rejuvenate HSCs.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2013.11.009