The role of myelin and oligodendrocytes in axonal energy metabolism

Highlights • Myelin is an insulator that can shield long axons from rapid access to metabolites. • Oligodendrocytes can ‘feed’ axons with glycolysis products such as lactate. • Loss of monocarboxylate transporters from oligodendrocytes causes axonopathy. • Oligodendrocyte dysfunction has been associ...

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Bibliographic Details
Published in:Current opinion in neurobiology 2013-12, Vol.23 (6), p.1065-1072
Main Authors: Saab, Aiman S, Tzvetanova, Iva D, Nave, Klaus-Armin
Format: Article
Language:English
Subjects:
Animals
Axons - metabolism
Energy Metabolism - physiology
Humans
Myelin Sheath - metabolism
Neurology
Oligodendroglia - metabolism
Psychiatry
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Summary:Highlights • Myelin is an insulator that can shield long axons from rapid access to metabolites. • Oligodendrocytes can ‘feed’ axons with glycolysis products such as lactate. • Loss of monocarboxylate transporters from oligodendrocytes causes axonopathy. • Oligodendrocyte dysfunction has been associated with ALS.
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2013.09.008