Simultaneous quantitative assessment of cerebral physiology using respiratory-calibrated MRI and near-infrared spectroscopy in healthy adults

Functional near-infrared spectroscopy (fNIRS) and functional MRI (fMRI) are non-invasive techniques used to relate activity in different brain regions to certain tasks. Respiratory calibration of the blood oxygen level dependent (BOLD) signal, and combined fNIRS–fMRI approaches have been used to qua...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2014-01, Vol.85, p.255-263
Main Authors: Alderliesten, T., De Vis, J.B., Lemmers, P.M.A., van Bel, F., Benders, M.J.N.L., Hendrikse, J., Petersen, E.T.
Format: Article
Language:English
Subjects:
Adult
Anatomy & physiology
ASL
Blood Gas Analysis
Blood Volume - physiology
Brain
Brain - anatomy & histology
Brain - physiology
Brain mapping
Calibration
Cerebrovascular Circulation - physiology
Data Interpretation, Statistical
Female
fMRI
fNIRS
Functional Neuroimaging - methods
Humans
Hyperoxia
Image Processing, Computer-Assisted - methods
Magnetic Resonance Imaging - methods
Male
Near-Infrared Spectroscopy
Optical Fibers
Oxygen Consumption - physiology
Respiratory Mechanics - physiology
Respiratory-calibrated MRI
Spectroscopy, Near-Infrared - methods
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Summary:Functional near-infrared spectroscopy (fNIRS) and functional MRI (fMRI) are non-invasive techniques used to relate activity in different brain regions to certain tasks. Respiratory calibration of the blood oxygen level dependent (BOLD) signal, and combined fNIRS–fMRI approaches have been used to quantify physiological subcomponents giving rise to the BOLD signal. A comparison of absolute oxygen metabolism parameters between MRI and NIRS, using spatially resolved (SRS) NIRS and respiratory calibrated MRI, could yield additional insight in the physiology underlying activation. Changes in the BOLD signal, cerebral blood flow (CBF), and oxygen saturation (SO2) were derived from a single MRI sequence during a respiratory challenge in healthy volunteers. These changes were compared to SO2 obtained by a single probe SRS NIRS setup. In addition, concentration changes in oxygenated (O2Hb), deoxygenated (HHb), and total haemoglobin (tHb), obtained by NIRS, were compared to the parameters obtained by MRI. NIRS SO2 correlated with end-tidal CO2 (0.83, p
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2013.07.015