Waist Circumference, Not Body Mass Index, Is Associated with Renal Function Decline in Korean Population: Hallym Aging Study. e59071

• Published in: PloS one 2013-03, Vol.8 (3)
• Main Authors: Oh, Hyunju, Quan, Shan Ai, Jeong, Jin-Young, Jang, Soong-Nang, Lee, Jung Eun, Kim, Dong-Hyun
• Format: Article
• Language: English
• ISSN: 1932-6203
• DOI: 10.1371/journal.pone.0059071

Background Prospective investigation of obesity and renal function decline in Asia is sparse. We examined the associations of body mass index (BMI) and waist circumference (WC) with renal function decline in a prospective study of Korean population. Methods A total of 454 participants who had baseline estimated glomerular filtration rate (eGFR) levels of more than 60 mL/min/1.73 m2 in Hallym Aging Study (HAS) were included and followed for 6 years. Renal function decline was defined as follows: (1) an eGFR decline greater than or equal to 3 mL/min/1.73 m2/year (n = 82 cases); (2) an eGFR decrease of 20% or greater (n = 87 cases) at follow-up; (3) an eGFR decrease of 20% greater at follow-up or eGFR decline greater than or equal to 3 mL/min/1.73 m2/year (n = 91 cases); and (4) an eGFR 95 cm in men or >90 cm in women with less than or equal to 90 cm in men or less than or equal to 85 cm in women, ORs (95% CIs) ranged from 2.31 (1.14-4.69) to 2.78 (1.19-6.50) for the 4 definitions of renal function decline (all p-values for trend