Clinical features and nigrostriatal dysfunction in patients with combined postural and resting tremors

Abstract Background The characteristics of clinical features and nigrostriatal dopaminergic dysfunction in patients with combined postural and resting tremors have been less clearly reported. Methods The present study examined 43 patients with a visible persistent bilateral postural tremor and a uni...

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Published in:Parkinsonism & related disorders 2013-12, Vol.19 (12), p.1118-1122
Main Authors: You, Sooyeoun, Kim, Mi-Jung, Kim, Sung Reul, Kim, Mi Jung, Oh, Minyoung, Kim, Jae Seung, Chung, Sun Ju
Format: Article
Language:English
Subjects:
[18F] FP-CIT PET
Aged
Aged, 80 and over
Basal ganglia
Brain - diagnostic imaging
Essential tremor
Female
Humans
Male
Middle Aged
Neurology
Parkinson's disease
Positron-Emission Tomography
Postural tremor
Radiopharmaceuticals
Resting tremor
Tremor - diagnosis
Tremor - diagnostic imaging
Tropanes
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Summary:Abstract Background The characteristics of clinical features and nigrostriatal dopaminergic dysfunction in patients with combined postural and resting tremors have been less clearly reported. Methods The present study examined 43 patients with a visible persistent bilateral postural tremor and a unilateral/bilateral resting tremor involving the hands and forearms. The patients had experienced tremors for more than 3 years, with no evidence of Parkinson's disease or other parkinsonian disorders. Visual and quantitative analyses of [18 F] N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane (FP-CIT) PET in 36 patients were performed. Seventeen age-matched normal controls were also studied. Results On visual analysis, 28 patients (78%) showed normal [18 F] FP-CIT uptake and eight (22%) showed significantly reduced uptake, suggesting nigrostriatal dopaminergic neuronal degeneration. The reduced [18 F] FP-CIT uptake was significantly associated with earlier age-at-onset of tremor and asymmetric presentation of resting tremor. On quantitative analysis, there were statistically significant differences in the [18 F] FP-CIT uptake ratio in the posterior putamen between patients with reduced uptake (2.37 ± 1.83) and patients with normal uptake (6.39 ± 1.35) ( P  
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2013.08.002