Identification and characterization of OmpL as a potential vaccine candidate for immune-protection against salmonellosis in mice

Highlights • OmpL is a widely distributed and conserved outer membrane protein. • rOmpL induces protective immunity against S . Typhimurium infection. • Anti-OmpL antibodies mediated killing of invasive S . Typhimurium. • Anti-rOmpL serum harbors a high bactericidal activity for Salmonella.

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Bibliographic Details
Published in:Vaccine 2013-06, Vol.31 (28), p.2930-2936
Main Authors: Yang, Youjun, Wan, Cuixiang, Xu, Hengyi, Wei, Hua
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
antibacterial properties
Antibiotics
Antigens
Applied microbiology
Bacteria
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Bacterial Proteins - chemistry
Bacterial Proteins - immunology
Bactericidal activity
Bacteriology
Biological and medical sciences
blood serum
cell-mediated immunity
cellular microenvironment
Developing countries
E coli
Fatalities
Female
Fever
Food contamination & poisoning
Fundamental and applied biological sciences. Psychology
Gastroenteritis
Human bacterial diseases
human diseases
humans
Immunization
Infections
Infectious diseases
Laboratory animals
LDCs
Medical sciences
Mice
Mice, Inbred BALB C
Microbiology
Miscellaneous
OmpL
outer membrane proteins
Paratyphis
pathogens
porins
Porins - chemistry
Porins - immunology
Protein Structure, Secondary
Proteins
Recombinant Proteins - chemistry
Recombinant Proteins - immunology
reverse transcriptase polymerase chain reaction
Salmonella
Salmonella Infections - immunology
Salmonella Infections - prevention & control
Salmonella typhimurium
Salmonella typhimurium - immunology
Salmonella Vaccines - immunology
Salmonellosis
serotypes
Studies
Typhoid
typhoid fever
Vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Subunit - immunology
Waterborne diseases
Western blotting
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Description
Summary:Highlights • OmpL is a widely distributed and conserved outer membrane protein. • rOmpL induces protective immunity against S . Typhimurium infection. • Anti-OmpL antibodies mediated killing of invasive S . Typhimurium. • Anti-rOmpL serum harbors a high bactericidal activity for Salmonella.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.04.044