Bisphenol‑A (BPA), BPA Glucuronide, and BPA Sulfate in Midgestation Umbilical Cord Serum in a Northern and Central California Population

Bisphenol-A (BPA) is an endocrine disrupting chemical used in numerous consumer products, resulting in universal exposure in the United States. Prenatal exposure to BPA is associated with numerous reproductive and developmental effects in animals. However, little is known about human fetal exposure...

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Bibliographic Details
Published in:Environmental science & technology 2013-11, Vol.47 (21), p.12477-12485
Main Authors: Gerona, Roy R, Woodruff, Tracey J, Dickenson, Carrie A, Pan, Janet, Schwartz, Jackie M, Sen, Saunak, Friesen, Matthew W, Fujimoto, Victor Y, Hunt, Patricia A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Benzhydryl Compounds - blood
Biological and medical sciences
Bisphenol A
California
Chemical and industrial products toxicology. Toxic occupational diseases
Chromatography, Liquid
Environmental Pollutants - blood
Female
Fetus - metabolism
Glucuronides - blood
Human exposure
Humans
Male
Mass Spectrometry
Medical sciences
Metabolism
Middle Aged
Phenols - blood
Population
Pregnancy
Prenatal development
Reference Standards
Reproducibility of Results
Sulfuric Acid Esters - blood
Toxicology
Umbilical cord
Umbilical Cord - metabolism
Various organic compounds
Young Adult
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Summary:Bisphenol-A (BPA) is an endocrine disrupting chemical used in numerous consumer products, resulting in universal exposure in the United States. Prenatal exposure to BPA is associated with numerous reproductive and developmental effects in animals. However, little is known about human fetal exposure or metabolism of BPA during midgestation. In the present study, we present a new liquid chromatography-tandem mass spectrometry method to directly measure concentrations of BPA and two predominant metabolic conjugatesBPA glucuronide and BPA sulfatein umbilical cord serum collected from elective second trimester pregnancy terminations. We detected at least one form of BPA in all umbilical cord serum samples: BPA (GM 0.16, range
ISSN:0013-936X
1520-5851
DOI:10.1021/es402764d