Outer membrane protein A (OmpA) from Shigella flexneri 2a: A promising subunit vaccine candidate

Highlights • Shigella flexneri 2a OmpA is crossreactive, conserved and surface exposed. • It gives 100% protection in mice against challenged with virulent S. flexneri 2a. • Both humoral and cell-mediated immunity are involved in that protective response. • OmpA coordinates innate and typ1-1 adaptiv...

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Bibliographic Details
Published in:Vaccine 2013-08, Vol.31 (36), p.3644-3650
Main Authors: Pore, Debasis, Chakrabarti, Manoj K
Format: Article
Language:English
Subjects:
Adaptive Immunity
Allergy and Immunology
Animals
Antigens, Bacterial - immunology
Applied microbiology
Bacterial Outer Membrane Proteins - immunology
Bacterial Vaccines - immunology
Bacteriology
Biological and medical sciences
CD4+ T cells
CD4-positive T-lymphocytes
cell-mediated immunity
chemokines
childhood
Cross Protection
Dysentery, Bacillary - prevention & control
Fundamental and applied biological sciences. Psychology
Gram-negative bacteria
Immunity, Cellular
Immunity, Humoral
Immunity, Innate
immunodominant epitopes
immunoglobulin A
immunoglobulin G
Macrophages
Mice
Microbiology
Miscellaneous
morbidity
mortality
Outer membrane protein A
outer membrane proteins
Shigella flexneri
Shigella flexneri - immunology
Shigella flexneri 2a
shigellosis
Toll-like receptor 2
Toll-Like Receptor 2 - immunology
Toll-like receptors
Vaccine
vaccine development
vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:Highlights • Shigella flexneri 2a OmpA is crossreactive, conserved and surface exposed. • It gives 100% protection in mice against challenged with virulent S. flexneri 2a. • Both humoral and cell-mediated immunity are involved in that protective response. • OmpA coordinates innate and typ1-1 adaptive immune responses. • TLR2 plays fundamental role in the convergence of innate and adaptive immunity.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.05.100