Intravenous immunoglobulin products contain specific antibodies to recombinant human tau protein

Intravenous immunoglobulin (IVIG) products are prepared from plasma immunoglobulins from healthy donors. Pilot studies suggest that IVIG may stabilize cognitive functioning in patients with mild-to-moderate Alzheimer's disease. This study measured antibodies to recombinant human tau protein in...

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Bibliographic Details
Published in:International immunopharmacology 2013-08, Vol.16 (4), p.424-428
Main Authors: Smith, Lynnae M., Coffey, Mary P., Klaver, Andrea C., Loeffler, David A.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Antibodies
Antibodies, Monoclonal - immunology
Antibodies, Monoclonal - isolation & purification
Blotting, Western
ELISA
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulins, Intravenous - chemistry
Immunoglobulins, Intravenous - immunology
Intravenous immunoglobulin
IVIG
Protein Binding
Recombinant Proteins
Tau
tau Proteins - genetics
tau Proteins - immunology
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Summary:Intravenous immunoglobulin (IVIG) products are prepared from plasma immunoglobulins from healthy donors. Pilot studies suggest that IVIG may stabilize cognitive functioning in patients with mild-to-moderate Alzheimer's disease. This study measured antibodies to recombinant human tau protein in the IVIG products Gammagard (Baxter), Gamunex (Talecris), and Flebogamma (Grifols). Anti-tau antibodies were measured by ELISA, subtracting IVIG's polyvalent binding from its binding to tau-coated wells to calculate specific anti-tau antibody levels. Because polyvalent binding of IVIG products may interfere with ELISA measurement of their specific antibody levels, the percentage of binding of each IVIG product to tau-coated wells that was specific for tau was also determined. Specific anti-tau antibodies were detected in all three IVIG products, with significant differences between these products (p
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2013.04.034