Sortase A inhibitory metabolites from the roots of Pulsatilla koreana

Three new lignans (3, 4, and 6) along with eight known lignans and phenyl propanoids were isolated from the dried roots of Pulsatilla koreana, an oriental folk medicine. Based upon the results of combined spectroscopic and chemical methods, the structures of new compounds were determined to be ligna...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2014-01, Vol.24 (1), p.44-48
Main Authors: Lee, Sooryun, Song, Inn-Hye, Lee, Jung-Ho, Yang, Woo-Young, Oh, Ki-Bong, Shin, Jongheon
Format: Article
Language:English
Subjects:
Aminoacyltransferases - antagonists & inhibitors
Aminoacyltransferases - metabolism
Bacterial Proteins - antagonists & inhibitors
Bacterial Proteins - metabolism
Cysteine Endopeptidases - metabolism
Dose-Response Relationship, Drug
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - isolation & purification
Enzyme Inhibitors - pharmacology
Humans
Lignans - chemistry
Lignans - isolation & purification
Lignans - pharmacology
Metabolites
Mouth - microbiology
Plant Roots - chemistry
Pulsatilla - chemistry
Pulsatilla koreana
Streptococcus mutans - enzymology
Structure-Activity Relationship
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Summary:Three new lignans (3, 4, and 6) along with eight known lignans and phenyl propanoids were isolated from the dried roots of Pulsatilla koreana, an oriental folk medicine. Based upon the results of combined spectroscopic and chemical methods, the structures of new compounds were determined to be lignan glycosides. Included among the known compounds are three compounds (5, 7, and 8) isolated first time from this plant as well as two compounds (2 and 11) previously reported only as synthetic derivatives. These compounds significantly inhibited the action of Sortase A from Streptococcus mutans OMZ65, an isolate from human oral cavity.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2013.12.006