AD pathology and cerebral infarctions are associated with memory and executive functioning one and five years before death

We provide rigorous psychometric evidence for distinct patterns of cognitive impairment for Alzheimer's disease (AD) and cerebral infarctions using 440 participants from the Religious Order Study. Latent variable models were used to decompose the effects of AD pathology and cerebral infarctions...

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Bibliographic Details
Published in:Journal of clinical and experimental neuropsychology 2013-01, Vol.35 (1), p.24-34
Main Authors: Yang, Frances M., Grigorenko, Alexander, Tommet, Doug, Farias, Sarah T., Mungas, Dan, Bennett, David A., Jones, Richard N., Crane, Paul K.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Aged
Aged, 80 and over
Algorithms
Alzheimer Disease - pathology
Alzheimer Disease - psychology
Alzheimer's disease
Biological and medical sciences
Cerebral Infarction - pathology
Cerebral Infarction - psychology
Cerebrovascular disease
Cognition Disorders - etiology
Cognition Disorders - psychology
Data Interpretation, Statistical
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease Progression
Educational Status
Executive Function - physiology
Female
Humans
Latent variable models
Male
Medical sciences
Memory - physiology
Memory, Short-Term - physiology
Middle Aged
Neurology
Neuropathology
Neuropsychological measures
Neuropsychological Tests
Organic mental disorders. Neuropsychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reaction Time - physiology
Vascular diseases and vascular malformations of the nervous system
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Summary:We provide rigorous psychometric evidence for distinct patterns of cognitive impairment for Alzheimer's disease (AD) and cerebral infarctions using 440 participants from the Religious Order Study. Latent variable models were used to decompose the effects of AD pathology and cerebral infarctions assessed at autopsy on overall cognition and specific neuropsychological tests at one and five years prior to death. Results support clinical and univariate psychometric analyses that memory impairment is more pronounced in AD, and executive impairment is more pronounced in the presence of cerebral infarctions. These specific effects are subtle relative to the stronger associations of both AD neuropathology and cerebral infarctions with overall levels of cognitive impairment.
ISSN:1380-3395
1744-411X
DOI:10.1080/13803395.2012.740001