Inactivated Schmallenberg virus prototype vaccines

Highlights • Five inactivated Schmallenberg virus prototype vaccines have been developed. • The new vaccines were tested in sheep and cattle, the major target species. • Four vaccine prototypes completely prevented viraemia after challenge infection. • The developed vaccines are promising candidates...

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Bibliographic Details
Published in:Vaccine 2013-08, Vol.31 (35), p.3558-3563
Main Authors: Wernike, Kerstin, Nikolin, Veljko M, Hechinger, Silke, Hoffmann, Bernd, Beer, Martin
Format: Article
Language:English
Subjects:
abnormal development
adults
adverse effects
Allergy and Immunology
Animals
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Antibody Formation - immunology
Antibody response
Antigens
Applied microbiology
Aqueous solutions
Biological and medical sciences
Bunyaviridae Infections - immunology
Bunyaviridae Infections - prevention & control
calves
Candidates
Cattle
Cattle Diseases - immunology
Cattle Diseases - prevention & control
Cloning
congenital abnormalities
cows
Disease
ewes
Female
fetal death
Fever
Fundamental and applied biological sciences. Psychology
Genomes
immunity
Immunization
Inactivated vaccine
Inactivation
Infections
Male
microbial growth
Microbiology
neutralizing antibodies
Orthobunyavirus
Orthobunyavirus - immunology
pathogens
Product development
Prototypes
RNA, Viral - blood
Ruminantia
Schmallenberg virus
Sheep
Sheep Diseases - immunology
Sheep Diseases - prevention & control
vaccination
Vaccination - veterinary
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
viral load
Viral Vaccines - immunology
viruses
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Description
Summary:Highlights • Five inactivated Schmallenberg virus prototype vaccines have been developed. • The new vaccines were tested in sheep and cattle, the major target species. • Four vaccine prototypes completely prevented viraemia after challenge infection. • The developed vaccines are promising candidates for the prevention of infection.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.05.062