Ubiquitination signals critical to regulatory T cell development and function

Protein ubiquitination has emerged as a crucial modulator of the immune system, participating in the control of T cell differentiation, intracellular signal transduction and the induction of immune tolerance. CD4+CD25+FOXP3+ regulatory T cells are a unique subset of cells that mediate central and pe...

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Bibliographic Details
Published in:International immunopharmacology 2013-07, Vol.16 (3), p.348-352
Main Authors: Chen, Zuojia, Luo, Xuerui, Lu, Ye, Zhu, Tao, Wang, Jinhu, Tsun, Andy, Li, Bin
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - metabolism
Animals
Deubiquitinase
Deubiquitinating Enzyme CYLD
E3 ligase
Forkhead Transcription Factors - metabolism
FOXP3
Humans
Proto-Oncogene Proteins c-cbl - metabolism
Regulatory T cell
Repressor Proteins - metabolism
T-Lymphocytes, Regulatory - physiology
Treg cell therapy
Tumor Suppressor Proteins - metabolism
Ubiquitin-Conjugating Enzymes - metabolism
Ubiquitin-Protein Ligases - metabolism
Ubiquitination
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Summary:Protein ubiquitination has emerged as a crucial modulator of the immune system, participating in the control of T cell differentiation, intracellular signal transduction and the induction of immune tolerance. CD4+CD25+FOXP3+ regulatory T cells are a unique subset of cells that mediate central and peripheral immune tolerance. In this review, we highlight our current understanding of the molecular mechanisms and signaling pathways that modulate protein ubiquitination in Treg cells, and how ubiquitination determines Treg cell development and function. Understanding how FOXP3 activity is regulated by ubiquitination and deubiquitination under molecular level will promote regulatory T cell therapy for treating inflammation in autoimmune disease, infection, transplantation and cancer.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2013.01.023