Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV

A set of sulfamides and sulfamates were synthesized and tested against several isoforms of carbonic anhydrase: CA I, CA II, CA VII, CA XII and CA XIV. The biological assays showed a broad range of inhibitory activity, and interesting results were found for several compounds in terms of activity (Ki

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2013-03, Vol.21 (6), p.1410-1418
Main Authors: Gavernet, Luciana, Gonzalez Funes, José L., Palestro, Pablo H., Bruno Blanch, Luis E., Estiu, Guillermina L., Maresca, Alfonso, Barrios, Ivana, Supuran, Claudiu T.
Format: Article
Language:English
Subjects:
Aromatics
Binding Sites
bioassays
Carbonate dehydratase
Carbonic anhydrase
Carbonic Anhydrase I - antagonists & inhibitors
Carbonic Anhydrase I - metabolism
Carbonic Anhydrase II - antagonists & inhibitors
Carbonic Anhydrase II - metabolism
Carbonic Anhydrase Inhibitors - chemical synthesis
Carbonic Anhydrase Inhibitors - chemistry
Carbonic Anhydrase Inhibitors - metabolism
Carbonic Anhydrases - chemistry
Carbonic Anhydrases - metabolism
Catalytic Domain
Docking
Humans
Inhibition pattern
Isoenzymes
isozymes
Molecular Docking Simulation
Molecular dynamic simulations
Molecular modelling
Protein Binding
sulfamates
sulfamide
Sulfamides
Sulfonamides - chemical synthesis
Sulfonamides - chemistry
Sulfonamides - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A set of sulfamides and sulfamates were synthesized and tested against several isoforms of carbonic anhydrase: CA I, CA II, CA VII, CA XII and CA XIV. The biological assays showed a broad range of inhibitory activity, and interesting results were found for several compounds in terms of activity (Ki
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2012.10.048