Histamine H3 receptor activation prevents dopamine D1 receptor-mediated inhibition of dopamine release in the rat striatum: A microdialysis study

• Published in: Neuroscience letters 2013-09, Vol.552, p.5-9
• Main Authors: Alfaro-Rodriguez, Alfonso, Alonso-Spilsbury, María, Arch-Tirado, Emilio, Gonzalez-Pina, Rigoberto, Arias-Montaño, José-Antonio, Bueno-Nava, Antonio
• Format: Article
• Language: English
• Subjects: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - administration & dosage; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - antagonists & inhibitors; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology; Animals; Corpus Striatum - drug effects; Corpus Striatum - metabolism; D1 receptor; Dopamine; Dopamine - metabolism; Dopamine Agonists - administration & dosage; Dopamine Agonists - pharmacology; Dopamine release; Drug Interactions; H3 receptor; Histamine; Histamine Agonists - administration & dosage; Histamine Agonists - pharmacology; Histamine H3 Antagonists - pharmacology; Imidazoles - administration & dosage; Imidazoles - antagonists & inhibitors; Imidazoles - pharmacology; Male; Microdialysis; Microinjections; Piperidines - administration & dosage; Piperidines - antagonists & inhibitors; Piperidines - pharmacology; Rats; Receptors, Dopamine D1 - physiology; Receptors, Histamine H3 - physiology; Striatum; Synaptic Transmission - drug effects; Synaptic Transmission - physiology
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2013.07.026

•Dopamine (DA) D1 and D2 receptors control DA release in rat striatum.•Histamine H3 receptors co-localize with D1Rs and D2Rs on striatal projection neurons.•In freely moving rats D1R activation reduces DA release as evaluated by microdialysis.•Histamine H3 receptor activation counteracts the effect of D1R stimulation.•The histaminergic system participates in the control of striatal DA release. Histamine H3 receptors (H3Rs) co-localize with dopamine (DA) D1 receptors (D1Rs) on striatal medium spiny neurons and functionally antagonize D1R-mediated responses. The intra-striatal administration of D1R agonists reduces DA release whereas D1R antagonists have the opposite effect. In this work, a microdialysis method was used to study the effect of co-activating D1 and H3 receptors on the release of DA from the rat dorsal striatum. Infusion of the D1R agonist SKF-38393 (0.5 and 1μM) significantly reduced DA release (26–58%), and this effect was prevented by co-administration of the H3R agonist immepip (10μM). In turn, the effect of immepip was blocked by the H3R antagonist thioperamide (10μM). Our results indicate that co-stimulation of post-synaptic D1 and H3 receptors may indirectly regulate basal DA release in the rat striatum and provide in vivo evidence for a functional interaction between D1 and H3 receptors in the basal ganglia.