The Normal Limits, Subclinical Significance, Related Metabolic Derangements and Distinct Biological Effects of Body Site-Specific Adiposity in Relatively Healthy Population. e61997

• Published in: PloS one 2013-04, Vol.8 (4)
• Main Authors: Yun, Chun-Ho, Bezerra, Hiram G, Wu, Tung-Hsin, Yang, Fei-Shih, Liu, Chuan-Chuan, Wu, Yih-Jer, Kuo, Jen-Yuan, Hung, Chung-Lieh, Lee, Jason Jeun-Shenn, Hou, Charles Jia-Yin
• Format: Article
• Language: English
• ISSN: 1932-6203
• DOI: 10.1371/journal.pone.0061997

Background The accumulation of visceral adipose tissue that occurs with normal aging is associated with increased cardiovascular risks. However, the clinical significance, biological effects, and related cardiometabolic derangements of body-site specific adiposity in a relatively healthy population have not been well characterized. Materials and Methods In this cross-sectional study, we consecutively enrolled 608 asymptomatic subjects (mean age: 47.3 years, 27% female) from 2050 subjects undergoing an annual health survey in Taiwan. We measured pericardial (PCF) and thoracic peri-aortic (TAT) adipose tissue volumes by 16-slice multi-detector computed tomography (MDCT) (Aquarius 3D Workstation, TeraRecon, San Mateo, CA, USA) and related these to clinical characteristics, body fat composition (Tanita 305 Corporation, Tokyo, Japan), coronary calcium score (CCS), serum insulin, high-sensitivity C-reactive protein (Hs-CRP) level and circulating leukocytes count. Metabolic risk was scored by Adult Treatment Panel III guidelines. Results TAT, PCF, and total body fat composition all increased with aging and higher metabolic scores (all p