MicroRNAs as potential clinical biomarkers: emerging approaches for their detection

Abstract MicroRNAs (miRNAs) have emerged as novel post-transcriptional regulators of gene expression. These short non-coding RNAs are involved in diverse biological processes and their dysregulation is often observed under diseased conditions. Therefore, miRNAs hold great potential as clinical bioma...

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Bibliographic Details
Published in:Biotechnic & histochemistry 2013-10, Vol.88 (7), p.373-387
Main Authors: Srivastava, SK, Bhardwaj, A, Leavesley, SJ, Grizzle, WE, Singh, S, Singh, AP
Format: Article
Language:English
Subjects:
biomarkers
Biomarkers - blood
clinical applications
detection
Gene expression
Gene Expression Regulation, Neoplastic - physiology
microRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNAs
Neoplasms - blood
Neoplasms - genetics
Neoplasms - metabolism
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Summary:Abstract MicroRNAs (miRNAs) have emerged as novel post-transcriptional regulators of gene expression. These short non-coding RNAs are involved in diverse biological processes and their dysregulation is often observed under diseased conditions. Therefore, miRNAs hold great potential as clinical biomarkers of physiological and pathological states and extensive efforts are underway to develop efficient approaches for their detection. We review recent advances and discuss the promises and pitfalls of emerging methods of miRNA profiling and detection.
ISSN:1052-0295
1473-7760
DOI:10.3109/10520295.2012.730153