Determinants of monovalent oral polio vaccine mutagenesis in vaccinated elderly people

Abstract Live oral poliovirus vaccine (OPV) strains can mutate and recombine during replication in the host. Trivalent OPV has long been used to restrain wild-type poliovirus in developing countries. However, recently WHO advocates using monovalent OPV (mOPV) to finally eradicate poliovirus world-wi...

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Bibliographic Details
Published in:Vaccine 2007-06, Vol.25 (24), p.4706-4714
Main Authors: Boot, Hein J, Sonsma, Jan, van Nunen, Femke, Abbink, Frithjofna, Kimman, Tjeerd G, Buisman, Anne-Marie
Format: Article
Language:English
Subjects:
Aged
Allergy and Immunology
Amino Acid Sequence
Amino Acid Substitution - genetics
Amino acids
Animals
Antibodies, Viral - blood
Applied microbiology
Biological and medical sciences
Capsid Proteins - genetics
Conflicts of interest
Developing countries
DNA Mutational Analysis
Epitopes - genetics
Excretion
Feces - virology
Fundamental and applied biological sciences. Psychology
Genome, Viral - genetics
Human viral diseases
Humans
Immune status
Infectious diseases
LDCs
Medical sciences
Mice
Mice, Transgenic
Microbiology
Miscellaneous
Molecular Sequence Data
Monovalent oral poliovirus vaccine
Mutation
Mutation analysis
Neutralization Tests
Phenotype
Poliomyelitis
Poliovirus - genetics
Poliovirus - isolation & purification
Poliovirus Vaccine, Oral - genetics
RNA, Viral - genetics
Vaccine-derived poliovirus
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Viral diseases of the nervous system
Virology
Virus Shedding
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Summary:Abstract Live oral poliovirus vaccine (OPV) strains can mutate and recombine during replication in the host. Trivalent OPV has long been used to restrain wild-type poliovirus in developing countries. However, recently WHO advocates using monovalent OPV (mOPV) to finally eradicate poliovirus world-wide. We analysed polioviruses recovered from the faeces of 101 elderly patients (divided into three groups by immune status) challenged with mOPV-1 or mOPV-3. A high number of nucleotide mutations was found in the viral capsid-protein-encoding regions. Some of these mutations caused amino acid changes in or near regions with neutralizing epitopes, especially in mOPV-1-derived strains. The quantities of mutations in recovered poliovirus strains correlated with prevaccination immune status (seronegatives have more mutations) and excretion duration. Duration of excretion appears to be the dominant factor for the accumulation of mutations in mOPV-derived strains in vaccinated elderly people.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2007.04.007