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Determinants of monovalent oral polio vaccine mutagenesis in vaccinated elderly people
Abstract Live oral poliovirus vaccine (OPV) strains can mutate and recombine during replication in the host. Trivalent OPV has long been used to restrain wild-type poliovirus in developing countries. However, recently WHO advocates using monovalent OPV (mOPV) to finally eradicate poliovirus world-wi...
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| Published in: | Vaccine 2007-06, Vol.25 (24), p.4706-4714 |
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| container_end_page | 4714 |
| container_issue | 24 |
| container_start_page | 4706 |
| container_title | Vaccine |
| container_volume | 25 |
| creator | Boot, Hein J Sonsma, Jan van Nunen, Femke Abbink, Frithjofna Kimman, Tjeerd G Buisman, Anne-Marie |
| description | Abstract Live oral poliovirus vaccine (OPV) strains can mutate and recombine during replication in the host. Trivalent OPV has long been used to restrain wild-type poliovirus in developing countries. However, recently WHO advocates using monovalent OPV (mOPV) to finally eradicate poliovirus world-wide. We analysed polioviruses recovered from the faeces of 101 elderly patients (divided into three groups by immune status) challenged with mOPV-1 or mOPV-3. A high number of nucleotide mutations was found in the viral capsid-protein-encoding regions. Some of these mutations caused amino acid changes in or near regions with neutralizing epitopes, especially in mOPV-1-derived strains. The quantities of mutations in recovered poliovirus strains correlated with prevaccination immune status (seronegatives have more mutations) and excretion duration. Duration of excretion appears to be the dominant factor for the accumulation of mutations in mOPV-derived strains in vaccinated elderly people. |
| doi_str_mv | 10.1016/j.vaccine.2007.04.007 |
| format | article |
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Trivalent OPV has long been used to restrain wild-type poliovirus in developing countries. However, recently WHO advocates using monovalent OPV (mOPV) to finally eradicate poliovirus world-wide. We analysed polioviruses recovered from the faeces of 101 elderly patients (divided into three groups by immune status) challenged with mOPV-1 or mOPV-3. A high number of nucleotide mutations was found in the viral capsid-protein-encoding regions. Some of these mutations caused amino acid changes in or near regions with neutralizing epitopes, especially in mOPV-1-derived strains. The quantities of mutations in recovered poliovirus strains correlated with prevaccination immune status (seronegatives have more mutations) and excretion duration. Duration of excretion appears to be the dominant factor for the accumulation of mutations in mOPV-derived strains in vaccinated elderly people.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2007.04.007</identifier><identifier>PMID: 17482726</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Aged ; Allergy and Immunology ; Amino Acid Sequence ; Amino Acid Substitution - genetics ; Amino acids ; Animals ; Antibodies, Viral - blood ; Applied microbiology ; Biological and medical sciences ; Capsid Proteins - genetics ; Conflicts of interest ; Developing countries ; DNA Mutational Analysis ; Epitopes - genetics ; Excretion ; Feces - virology ; Fundamental and applied biological sciences. Psychology ; Genome, Viral - genetics ; Human viral diseases ; Humans ; Immune status ; Infectious diseases ; LDCs ; Medical sciences ; Mice ; Mice, Transgenic ; Microbiology ; Miscellaneous ; Molecular Sequence Data ; Monovalent oral poliovirus vaccine ; Mutation ; Mutation analysis ; Neutralization Tests ; Phenotype ; Poliomyelitis ; Poliovirus - genetics ; Poliovirus - isolation & purification ; Poliovirus Vaccine, Oral - genetics ; RNA, Viral - genetics ; Vaccine-derived poliovirus ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Viral diseases ; Viral diseases of the nervous system ; Virology ; Virus Shedding</subject><ispartof>Vaccine, 2007-06, Vol.25 (24), p.4706-4714</ispartof><rights>Elsevier Ltd</rights><rights>2007 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jun 11, 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-2eba62ba510406e915b30ef40932d697d81352aa8c8070d434b7c2d08609d0a03</citedby><cites>FETCH-LOGICAL-c509t-2eba62ba510406e915b30ef40932d697d81352aa8c8070d434b7c2d08609d0a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18803654$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17482726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boot, Hein J</creatorcontrib><creatorcontrib>Sonsma, Jan</creatorcontrib><creatorcontrib>van Nunen, Femke</creatorcontrib><creatorcontrib>Abbink, Frithjofna</creatorcontrib><creatorcontrib>Kimman, Tjeerd G</creatorcontrib><creatorcontrib>Buisman, Anne-Marie</creatorcontrib><title>Determinants of monovalent oral polio vaccine mutagenesis in vaccinated elderly people</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract Live oral poliovirus vaccine (OPV) strains can mutate and recombine during replication in the host. Trivalent OPV has long been used to restrain wild-type poliovirus in developing countries. However, recently WHO advocates using monovalent OPV (mOPV) to finally eradicate poliovirus world-wide. We analysed polioviruses recovered from the faeces of 101 elderly patients (divided into three groups by immune status) challenged with mOPV-1 or mOPV-3. A high number of nucleotide mutations was found in the viral capsid-protein-encoding regions. Some of these mutations caused amino acid changes in or near regions with neutralizing epitopes, especially in mOPV-1-derived strains. The quantities of mutations in recovered poliovirus strains correlated with prevaccination immune status (seronegatives have more mutations) and excretion duration. Duration of excretion appears to be the dominant factor for the accumulation of mutations in mOPV-derived strains in vaccinated elderly people.</description><subject>Aged</subject><subject>Allergy and Immunology</subject><subject>Amino Acid Sequence</subject><subject>Amino Acid Substitution - genetics</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Capsid Proteins - genetics</subject><subject>Conflicts of interest</subject><subject>Developing countries</subject><subject>DNA Mutational Analysis</subject><subject>Epitopes - genetics</subject><subject>Excretion</subject><subject>Feces - virology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genome, Viral - genetics</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immune status</subject><subject>Infectious diseases</subject><subject>LDCs</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Monovalent oral poliovirus vaccine</subject><subject>Mutation</subject><subject>Mutation analysis</subject><subject>Neutralization Tests</subject><subject>Phenotype</subject><subject>Poliomyelitis</subject><subject>Poliovirus - genetics</subject><subject>Poliovirus - isolation & purification</subject><subject>Poliovirus Vaccine, Oral - genetics</subject><subject>RNA, Viral - genetics</subject><subject>Vaccine-derived poliovirus</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Viral diseases</subject><subject>Viral diseases of the nervous system</subject><subject>Virology</subject><subject>Virus Shedding</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkl2r1DAQhosonvXoT1AKInjTOvlo094ocvyEA174gXchTaaSNU32JO3C_ntTtrBwbrwaCM-8M3mYonhOoCZA2jf7-qi0th5rCiBq4HUuD4od6QSraEO6h8UOaMsrTuD3VfEkpT0ANIz0j4srInhHBW13xa8POGOcrFd-TmUYyyn4cFQO_VyGqFx5CM6GcptVTsus_qDHZFNp_fasZjQlOoPRncoDhoPDp8WjUbmEz7Z6Xfz89PHHzZfq9tvnrzfvbyvdQD9XFAfV0kE1BDi02JNmYIAjh55R0_bCdIQ1VKlOdyDAcMYHoamBroXegAJ2Xbw-5x5iuFswzXKySaNzymNYkiRNttILQVf05T10H5bo83aZavqcKUiXqeZM6RhSijjKQ7STiidJQK7i5V5uMuQqXgKXueS-F1v6MkxoLl2b6Qy82gCVtHJjVF7bdOG6Dljb8My9O3OYtR0tRpm0Ra_R2Ih6libY_67y9l6CdtbbPPQvnjBdfi0TlSC_r1eyHkk2DJwIxv4BF1S3ug</recordid><startdate>20070611</startdate><enddate>20070611</enddate><creator>Boot, Hein J</creator><creator>Sonsma, Jan</creator><creator>van Nunen, Femke</creator><creator>Abbink, Frithjofna</creator><creator>Kimman, Tjeerd G</creator><creator>Buisman, Anne-Marie</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7U2</scope></search><sort><creationdate>20070611</creationdate><title>Determinants of monovalent oral polio vaccine mutagenesis in vaccinated elderly people</title><author>Boot, Hein J ; Sonsma, Jan ; van Nunen, Femke ; Abbink, Frithjofna ; Kimman, Tjeerd G ; Buisman, Anne-Marie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-2eba62ba510406e915b30ef40932d697d81352aa8c8070d434b7c2d08609d0a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Allergy and Immunology</topic><topic>Amino Acid Sequence</topic><topic>Amino Acid Substitution - genetics</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Capsid Proteins - genetics</topic><topic>Conflicts of interest</topic><topic>Developing countries</topic><topic>DNA Mutational Analysis</topic><topic>Epitopes - genetics</topic><topic>Excretion</topic><topic>Feces - virology</topic><topic>Fundamental and applied biological sciences. 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Frithjofna</au><au>Kimman, Tjeerd G</au><au>Buisman, Anne-Marie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determinants of monovalent oral polio vaccine mutagenesis in vaccinated elderly people</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2007-06-11</date><risdate>2007</risdate><volume>25</volume><issue>24</issue><spage>4706</spage><epage>4714</epage><pages>4706-4714</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Abstract Live oral poliovirus vaccine (OPV) strains can mutate and recombine during replication in the host. Trivalent OPV has long been used to restrain wild-type poliovirus in developing countries. However, recently WHO advocates using monovalent OPV (mOPV) to finally eradicate poliovirus world-wide. We analysed polioviruses recovered from the faeces of 101 elderly patients (divided into three groups by immune status) challenged with mOPV-1 or mOPV-3. A high number of nucleotide mutations was found in the viral capsid-protein-encoding regions. Some of these mutations caused amino acid changes in or near regions with neutralizing epitopes, especially in mOPV-1-derived strains. The quantities of mutations in recovered poliovirus strains correlated with prevaccination immune status (seronegatives have more mutations) and excretion duration. Duration of excretion appears to be the dominant factor for the accumulation of mutations in mOPV-derived strains in vaccinated elderly people.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17482726</pmid><doi>10.1016/j.vaccine.2007.04.007</doi><tpages>9</tpages></addata></record> |
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| source | Elsevier |
| subjects | Aged Allergy and Immunology Amino Acid Sequence Amino Acid Substitution - genetics Amino acids Animals Antibodies, Viral - blood Applied microbiology Biological and medical sciences Capsid Proteins - genetics Conflicts of interest Developing countries DNA Mutational Analysis Epitopes - genetics Excretion Feces - virology Fundamental and applied biological sciences. Psychology Genome, Viral - genetics Human viral diseases Humans Immune status Infectious diseases LDCs Medical sciences Mice Mice, Transgenic Microbiology Miscellaneous Molecular Sequence Data Monovalent oral poliovirus vaccine Mutation Mutation analysis Neutralization Tests Phenotype Poliomyelitis Poliovirus - genetics Poliovirus - isolation & purification Poliovirus Vaccine, Oral - genetics RNA, Viral - genetics Vaccine-derived poliovirus Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral diseases Viral diseases of the nervous system Virology Virus Shedding |
| title | Determinants of monovalent oral polio vaccine mutagenesis in vaccinated elderly people |
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