Gray matter and intrinsic network changes in the posterior cingulate cortex after selective serotonin reuptake inhibitor intake

Preclinical studies have demonstrated that serotonin (5-HT) challenge changes neuronal circuitries and microarchitecture. However, evidence in human subjects is missing. Pharmacologic magnetic resonance imaging (phMRI) applying selective 5-HT reuptake inhibitors (SSRIs) and high-resolution structura...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2014-01, Vol.84, p.236-244
Main Authors: Kraus, Christoph, Ganger, Sebastian, Losak, Jan, Hahn, Andreas, Savli, Markus, Kranz, Georg S., Baldinger, Pia, Windischberger, Christian, Kasper, Siegfried, Lanzenberger, Rupert
Format: Article
Language:English
Subjects:
Adult
Binding sites
Biological and medical sciences
Brain
Brain Mapping - methods
Cross-Over Studies
Double-Blind Method
Female
Fundamental and applied biological sciences. Psychology
Gray Matter - anatomy & histology
Gray Matter - drug effects
Gray Matter - physiology
Gyrus Cinguli - anatomy & histology
Gyrus Cinguli - drug effects
Gyrus Cinguli - physiology
Humans
Male
Multimodal Imaging - methods
Nerve Net - anatomy & histology
Nerve Net - drug effects
Nerve Net - physiology
Neuronal Plasticity - drug effects
Neuronal Plasticity - physiology
Placebo Effect
Plasma
Reference Values
Serotonin - metabolism
Serotonin Uptake Inhibitors - pharmacology
Studies
Substance abuse treatment
Vertebrates: nervous system and sense organs
Volumetric analysis
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Summary:Preclinical studies have demonstrated that serotonin (5-HT) challenge changes neuronal circuitries and microarchitecture. However, evidence in human subjects is missing. Pharmacologic magnetic resonance imaging (phMRI) applying selective 5-HT reuptake inhibitors (SSRIs) and high-resolution structural and functional brain assessment is able to demonstrate the impact of 5-HT challenge on neuronal network morphology and functional activity. To determine how SSRIs induce changes in gray matter and neuronal activity, we conducted a longitudinal study using citalopram and escitalopram. Seventeen healthy subjects completed a structural and functional phMRI study with randomized, cross-over, placebo-controlled, double-blind design. Significant gray matter increases were observed (among other regions) in the posterior cingulate cortex (PCC) and the ventral precuneus after SSRI intake of 10days, while decreases were observed within the pre- and postcentral gyri (all P
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2013.08.036