Roux-en-Y gastric bypass surgery in rats alters gut microbiota profile along the intestine

Roux-en-Y gastric bypass (RYGB) surgery might modify the gut microbiota composition differently in the three distinct anatomical sections of the small intestine compared to sham surgery. We showed that RYGB induced changes in the microbiota of the alimentary limb and the common channel resembling th...

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Bibliographic Details
Published in:Physiology & behavior 2013-07, Vol.119, p.92-96
Main Authors: Osto, Melania, Abegg, Kathrin, Bueter, Marco, le Roux, Carel W, Cani, Patrice D, Lutz, Thomas A
Format: Article
Language:English
Subjects:
Animals
Bariatric surgery
Behavioral psychophysiology
Biological and medical sciences
dieting
energy balance
Fundamental and applied biological sciences. Psychology
Gastric Bypass - adverse effects
GLP-1
Gut microbiota
hormones
intestinal microorganisms
Intestine, Small - microbiology
Male
Microbiota
prebiotics
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
small intestine
weight loss
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Summary:Roux-en-Y gastric bypass (RYGB) surgery might modify the gut microbiota composition differently in the three distinct anatomical sections of the small intestine compared to sham surgery. We showed that RYGB induced changes in the microbiota of the alimentary limb and the common channel resembling those seen after prebiotic treatment or weight loss by dieting. These changes may be associated with altered production of intestinal hormones known to control energy balance. Postsurgical modulation of gut microbiota may significantly contribute to the beneficial metabolic effects of RYGB surgery.
ISSN:0031-9384
1873-507X
DOI:10.1016/j.physbeh.2013.06.008