Immunoglobulin A Nephropathy: A Review of Current Literature on Emerging Pathophysiology

Immunoglobulin (Ig) A nephropathy is one of the most common causes of glomerulonephritis worldwide. Its prognosis can be totally different in various patient populations, ranging from asymptomatic slow progression to end-stage renal disease in as much as 40% of patients in few months to years. This...

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Bibliographic Details
Published in:The American journal of the medical sciences 2014-03, Vol.347 (3), p.249-253
Main Authors: Pillai, Unnikrishnan, MD, Bhat, Zeenat, MD, Balabhadraputani, Krishna, MD
Format: Article
Language:English
Subjects:
Galactose-deficient IgA1
Glomerulonephritis, IGA - diagnosis
Glomerulonephritis, IGA - etiology
Humans
IgA nephropathy
Internal Medicine
Key Indexing Terms
N-acetylgalactosamine
Prognosis
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Summary:Immunoglobulin (Ig) A nephropathy is one of the most common causes of glomerulonephritis worldwide. Its prognosis can be totally different in various patient populations, ranging from asymptomatic slow progression to end-stage renal disease in as much as 40% of patients in few months to years. This disease process can be idiopathic, or it can be associated with a variety of disease processes. Various risk stratification scoring systems are available, which can predict the long-term outcome. New evidences are also emerging that IgA nephropathy is an autoimmune disease with a known antigen, galactose-deficient IgA1, which can elicit an autoantibody response and formation of immune complexes that are deposited in the mesangium.
ISSN:0002-9629
1538-2990
DOI:10.1097/MAJ.0b013e31829406a0