Inflammatory status modulates plasma lipid and inflammatory marker responses to kiwifruit consumption in hypercholesterolaemic men

• Published in: Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2014-01, Vol.24 (1), p.91-99
• Main Authors: Gammon, C.S, Kruger, R, Conlon, C.A, von Hurst, P.R, Jones, B, Stonehouse, W
• Format: Article
• Language: English
• Subjects: Adult; Aged; Apolipoprotein A-I - blood; Apolipoproteins B - blood; Biomarkers - blood; C-reactive protein; C-Reactive Protein - metabolism; Cardiovascular; Cardiovascular risk; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Cross-Over Studies; Fruit; Humans; Hypercholesterolemia - diet therapy; Inflammation; Inflammation - diet therapy; Interleukin-10 - blood; Interleukin-6 - blood; Kiwifruit; Lipids; Male; Middle Aged; Motor Activity; Tumor Necrosis Factor-alpha - blood
• ISSN: 0939-4753; 1590-3729
• DOI: 10.1016/j.numecd.2013.06.001

Abstract Background and aims Kiwifruit has the potential to improve markers of metabolic dysfunction, but the response may be influenced by inflammatory state. We aimed to investigate whether inflammatory state would modulate the effect of consuming two green kiwifruit daily on plasma lipids and markers of inflammation. Methods and results Eighty-five hypercholesterolaemic men completed a 4-week healthy diet run-in, before randomisation to a controlled cross-over study of two 4-week interventions of two green kiwifruit/day plus healthy diet (intervention) or healthy diet alone (control). Anthropometric measures and fasting blood samples (plasma lipids, serum apolipoproteins A1 and B, high-sensitivity C-reactive protein (hs-CRP) and interleukin (IL)-6, tumour necrosis factor-alpha (TNF-α) and IL-10) were taken at baseline, 4 and 8 weeks. Subjects were divided into low and medium inflammatory groups, using pre-intervention hs-CRP concentrations (hs-CRP