Taurine mitigates cognitive impairment induced by chronic co-exposure of male Wistar rats to chlorpyrifos and lead acetate

Highlight • Chlorpyrifos and lead co-exposure induced oxidative stress and cognitive impairment. • Oxidative stress and cognitive impairment were mitigated by taurine. • Taurine is neuroprotective in Wistar rats co-exposed to chlorpyrifos and lead.

Saved in:
Bibliographic Details
Published in:Environmental toxicology and pharmacology 2014-01, Vol.37 (1), p.315-325
Main Authors: Akande, M.G, Aliu, Y.O, Ambali, S.F, Ayo, J.O
Format: Article
Language:English
Subjects:
Acetylcholinesterase - metabolism
Animals
Antioxidants - therapeutic use
Brain - drug effects
Brain - metabolism
Brain - pathology
Catalase - metabolism
Chlorpyrifos
Chlorpyrifos - toxicity
Cholinesterase Inhibitors - toxicity
Cognition
Cognition Disorders - drug therapy
Emergency
Environmental Pollutants - toxicity
Glutathione Peroxidase - metabolism
Insecticides - toxicity
Lead acetate
Male
Malondialdehyde - metabolism
Memory, Short-Term - drug effects
Neuroprotection
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Organometallic Compounds - toxicity
Oxidative stress
Oxidative Stress - drug effects
Rats
Rats, Wistar
Superoxide Dismutase - metabolism
Taurine
Taurine - pharmacology
Taurine - therapeutic use
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlight • Chlorpyrifos and lead co-exposure induced oxidative stress and cognitive impairment. • Oxidative stress and cognitive impairment were mitigated by taurine. • Taurine is neuroprotective in Wistar rats co-exposed to chlorpyrifos and lead.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2013.11.023