Phospholipid and guanine nucleotide sensitive properties of the smooth muscle adenylate cyclase catalytic unit

The adenylate cyclase catalytic unit was partially purified from uterine smooth muscle. Guanine nucleotide inhibited catalysis. The catalytic unit was also phospholipid sensitive. Properties suggest the catalytic unit has both polar head group and acyl chain requirements for phospholipid binding.

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Bibliographic Details
Published in:Biochemistry (Easton) 1988-07, Vol.27 (14), p.5323-5328
Main Authors: Krall, J. Frederick, Leshon, Steven C, Korenman, Stanley G
Format: Article
Language:English
Subjects:
adenylate cyclase
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
guanine nucleotides
Lyases
phospholipids
smooth muscle
uterus
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Description
Summary:The adenylate cyclase catalytic unit was partially purified from uterine smooth muscle. Guanine nucleotide inhibited catalysis. The catalytic unit was also phospholipid sensitive. Properties suggest the catalytic unit has both polar head group and acyl chain requirements for phospholipid binding.
ISSN:0006-2960
1520-4995
DOI:10.1021/bi00414a056