Pharmacokinetics and Safety of Resveratrol Derivatives in Humans after Oral Administration of Melinjo (Gnetum gnemon L.) Seed Extract Powder

Fruits and seeds of melinjo (Gnetum gnemon L.) are resveratrol derivative-rich materials. Pharmacokinetics of resveratrol derivatives in healthy volunteers after oral administration of 1000 mg of melinjo seed extract (MSE) powder were assessed and compared with those after oral dosing of trans-resve...

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Published in:Journal of agricultural and food chemistry 2014-02, Vol.62 (8), p.1999-2007
Main Authors: Tani, Hiroko, Hikami, Susumu, Iizuna, Sanae, Yoshimatsu, Maiko, Asama, Takashi, Ota, Hidetaka, Kimura, Yuka, Tatefuji, Tomoki, Hashimoto, Ken, Higaki, Kazutaka
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
enzymatic hydrolysis
Female
fruits
Gnetum - chemistry
Gnetum gnemon
Healthy Volunteers
Humans
hydrolysis
Male
oral administration
pharmacokinetics
Plant Extracts - administration & dosage
Plant Extracts - adverse effects
Plant Extracts - pharmacokinetics
Powders - administration & dosage
Powders - adverse effects
Powders - pharmacokinetics
resveratrol
seed extracts
seeds
Seeds - chemistry
Stilbenes - administration & dosage
Stilbenes - adverse effects
Stilbenes - pharmacokinetics
volunteers
Young Adult
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Summary:Fruits and seeds of melinjo (Gnetum gnemon L.) are resveratrol derivative-rich materials. Pharmacokinetics of resveratrol derivatives in healthy volunteers after oral administration of 1000 mg of melinjo seed extract (MSE) powder were assessed and compared with those after oral dosing of trans-resveratrol (tRV) powder containing 4.8 mg of tRV only, equivalent to the content in 1000 mg MSE powder. Plasma tRV concentrations with enzymatic hydrolysis were maintained over 24 h, with a t max of 12 h and a mean residence time (MRT) of 14 h, 5 and 2 times higher than those for tRV powder intake, respectively. Gnetin C, a resveratrol dimer, with hydrolysis was maintained in plasma for >96 h with a 36 h MRT. With repeated doses once daily for 28 days, plasma tRV and gnetin C concentrations with hydrolysis were in good agreement with the theoretical curves. MSE powder was well tolerated up to the oral dosing of 5000 mg with no serious adverse events.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf4048435