Association Between Inherited Thrombophilia and Impaired Right Ventricular Function in Deep Vein Thrombosis Without Symptomatic Pulmonary Embolism

The aim was to evaluate the right ventricular function in patients with inherited thrombophilia and deep vein thrombosis (DVT) without pulmonary embolism. A total of 38 patients with DVT without symptomatic pulmonary embolism and 30 patients with varicose veins were enrolled. Clinical data, echocard...

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Bibliographic Details
Published in:Clinical and applied thrombosis/hemostasis 2014-04, Vol.20 (3), p.270-277
Main Authors: Asgun, Halil Fatih, Kirilmaz, Bahadir, Saygi, Serkan, Ozturk, Okan, Silan, Fatma, Karatag, Ozan, Kosar, Sule, Ozdemir, Ozturk
Format: Article
Language:English
Subjects:
Echocardiography
Embolisms
Female
Genetic Predisposition to Disease
Health risk assessment
Humans
Male
Middle Aged
Polymorphism
Polymorphism, Genetic
Pulmonary Embolism - genetics
Pulmonary Embolism - physiopathology
Pulmonary embolisms
Risk Factors
Thrombophilia - genetics
Thrombophilia - physiopathology
Thrombosis
Venous Thrombosis - genetics
Venous Thrombosis - physiopathology
Ventricular Function, Right
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Summary:The aim was to evaluate the right ventricular function in patients with inherited thrombophilia and deep vein thrombosis (DVT) without pulmonary embolism. A total of 38 patients with DVT without symptomatic pulmonary embolism and 30 patients with varicose veins were enrolled. Clinical data, echocardiography, and 2 thrombophilic mutations were analyzed. Factor V Leiden (FVL) polymorphism was significantly frequent in the study group (P = .007). The difference in prothrombin G20210A polymorphism between the study and control groups was at a near-significant level (P = .058). There was statistically significant decrease in tricuspid annular plane systolic excursion values in patients with FVL and prothrombin G20210A polymorphism. Combined FVL and prothrombin G20210A polymorphisms were more closely related to the decrease in this value (P = .006). Deep vein thrombosis had no additional adverse effects on right ventricle. Impaired right ventricular systolic function occurs in FVL and prothrombin G20210A polymorphisms.
ISSN:1076-0296
1938-2723
DOI:10.1177/1076029612460426