Potentiation of neutrophils aggregation by human leukocyte inhibitory factor

The current studies were designed to extend the authors' investigations on the ability of the lymphokine leukocyte inhibitory factor (LIF) to function as a neutrophil activator. Specifically, the authors investigated whether LIF could modulate neutrophil (PMN) aggregation. Aggregation was measu...

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Bibliographic Details
Published in:Inflammation 1988-01, Vol.12 (3), p.203-212
Main Authors: Schainberg, H, Borish, L, Rocklin, R E
Format: Article
Language:English
Online Access:Get full text
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Summary:The current studies were designed to extend the authors' investigations on the ability of the lymphokine leukocyte inhibitory factor (LIF) to function as a neutrophil activator. Specifically, the authors investigated whether LIF could modulate neutrophil (PMN) aggregation. Aggregation was measured as the increase in light transmission using a Payton aggregometer. As aggregation is thought to represent the in vitro correlate to adherence, these studies provide further evidence for a proinflammatory role for LIF in vivo
ISSN:0360-3997