Lower beta cell function relates to sustained higher glycated albumin to glycated hemoglobin ratio in Japanese patients with type 2 diabetes

The aim of this study was to clarify the relationship between baseline beta cell function and future glycated albumin (GA) to glycated hemoglobin ratio (GA/HbA1c) in patients with type 2 diabetes. In our retrospective cohort, 210 type 2 diabetic patients who had been admitted to our hospital and in...

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Bibliographic Details
Published in:Endocrine Journal 2014, Vol.61(2), pp.149-157
Main Authors: Saisho, Yoshifumi, Tanaka, Kumiko, Abe, Takayuki, Kawai, Toshihide, Itoh, Hiroshi
Format: Article
Language:English
Subjects:
Aged
Asian Continental Ancestry Group
Beta cell function
C-peptide
C-Peptide - blood
Diabetes Mellitus, Type 2 - physiopathology
Female
Glycated albumin
Glycated hemoglobin
Glycated Hemoglobin A - metabolism
Humans
Insulin-Secreting Cells - physiology
Male
Middle Aged
Regression Analysis
Retrospective Studies
Serum Albumin - metabolism
Type 2 diabetes
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Summary:The aim of this study was to clarify the relationship between baseline beta cell function and future glycated albumin (GA) to glycated hemoglobin ratio (GA/HbA1c) in patients with type 2 diabetes. In our retrospective cohort, 210 type 2 diabetic patients who had been admitted to our hospital and in whom HbA1c and GA had been measured at baseline and 2 years after admission were included in this study. Baseline beta cell function was assessed by postprandial C-peptide immunoreactivity index (PCPRI) during admission. With intensification of treatment during admission, HbA1c and GA were significantly decreased 1 year and 2 years after admission. While baseline HbA1c was not significantly correlated with HbA1c after 2 years, baseline GA/HbA1c was strongly correlated with GA/HbA1c after 2 years (r = 0.575, P
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.EJ13-0376