Lower beta cell function relates to sustained higher glycated albumin to glycated hemoglobin ratio in Japanese patients with type 2 diabetes

The aim of this study was to clarify the relationship between baseline beta cell function and future glycated albumin (GA) to glycated hemoglobin ratio (GA/HbA1c) in patients with type 2 diabetes. In our retrospective cohort, 210 type 2 diabetic patients who had been admitted to our hospital and in...

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Published in:Endocrine Journal 2014, Vol.61(2), pp.149-157
Main Authors: Saisho, Yoshifumi, Tanaka, Kumiko, Abe, Takayuki, Kawai, Toshihide, Itoh, Hiroshi
Format: Article
Language:English
Subjects:
Aged
Asian Continental Ancestry Group
Beta cell function
C-peptide
C-Peptide - blood
Diabetes Mellitus, Type 2 - physiopathology
Female
Glycated albumin
Glycated hemoglobin
Glycated Hemoglobin A - metabolism
Humans
Insulin-Secreting Cells - physiology
Male
Middle Aged
Regression Analysis
Retrospective Studies
Serum Albumin - metabolism
Type 2 diabetes
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cited_by cdi_FETCH-LOGICAL-c498t-1112cbd0636c035f60f3fe44b106d634c1199c42d32cc5f907639a2135fc1e5d3
cites cdi_FETCH-LOGICAL-c498t-1112cbd0636c035f60f3fe44b106d634c1199c42d32cc5f907639a2135fc1e5d3
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container_issue 2
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container_title Endocrine Journal
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creator Saisho, Yoshifumi
Tanaka, Kumiko
Abe, Takayuki
Kawai, Toshihide
Itoh, Hiroshi
description The aim of this study was to clarify the relationship between baseline beta cell function and future glycated albumin (GA) to glycated hemoglobin ratio (GA/HbA1c) in patients with type 2 diabetes. In our retrospective cohort, 210 type 2 diabetic patients who had been admitted to our hospital and in whom HbA1c and GA had been measured at baseline and 2 years after admission were included in this study. Baseline beta cell function was assessed by postprandial C-peptide immunoreactivity index (PCPRI) during admission. With intensification of treatment during admission, HbA1c and GA were significantly decreased 1 year and 2 years after admission. While baseline HbA1c was not significantly correlated with HbA1c after 2 years, baseline GA/HbA1c was strongly correlated with GA/HbA1c after 2 years (r = 0.575, P
doi_str_mv 10.1507/endocrj.EJ13-0376
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source J-STAGE (Japan Science & Technology Information Aggregator, Electronic) - Open Access English articles
subjects Aged
Asian Continental Ancestry Group
Beta cell function
C-peptide
C-Peptide - blood
Diabetes Mellitus, Type 2 - physiopathology
Female
Glycated albumin
Glycated hemoglobin
Glycated Hemoglobin A - metabolism
Humans
Insulin-Secreting Cells - physiology
Male
Middle Aged
Regression Analysis
Retrospective Studies
Serum Albumin - metabolism
Type 2 diabetes
title Lower beta cell function relates to sustained higher glycated albumin to glycated hemoglobin ratio in Japanese patients with type 2 diabetes
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