To freeze or not to freeze peripheral blood stem cells prior to allogeneic transplantation from matched related donors

Background The standard practice in allogeneic stem cell transplant (alloSCT) is to infuse peripheral blood stem cells (PBSC) the same day or the day after collection once the patient has received conditioning regimen. To obtain and freeze PBSC prior to SCT would be desirable to get a better logisti...

Full description

Saved in:
Bibliographic Details
Published in:European journal of haematology 2013-11, Vol.91 (5), p.448-455
Main Authors: Parody, Rocío, Caballero, Dolores, Márquez-Malaver, Francisco J., Vázquez, Lourdes, Saldaña, Raquel, Madrigal, Ma Dolores, Calderón, Cristina, Carrillo, Estrella, Lopez-Corral, Lucía, Espigado, Ildefonso, Carmona, Magdalena, López-Villar, Olga, Pérez-Simón, Jose A.
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Aged
allogeneic transplant
Chronic Disease
Cryopreservation
Female
Graft vs Host Disease - mortality
Graft vs Host Disease - pathology
Hematologic Neoplasms - mortality
Hematologic Neoplasms - pathology
Hematologic Neoplasms - therapy
Histocompatibility Testing
HLA Antigens - immunology
Humans
Male
Middle Aged
Myeloablative Agonists - therapeutic use
Peripheral Blood Stem Cell Transplantation - methods
Recurrence
Retrospective Studies
Survival Analysis
Tissue Donors
to freeze
Transplantation Conditioning
Transplantation, Homologous
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The standard practice in allogeneic stem cell transplant (alloSCT) is to infuse peripheral blood stem cells (PBSC) the same day or the day after collection once the patient has received conditioning regimen. To obtain and freeze PBSC prior to SCT would be desirable to get a better logistic and to confirm the quality of the product. Unfortunately, studies comparing both approaches are lacking. Aim In this retrospective study, we analyze the impact of using fresh (N: 107) or previously frozen PBSC (N: 224) on overall outcomes among patients consecutively undergoing alloPBSCT from a matched related donor. Results Granulocyte engraftment (>500/mcl × 3 days) was faster in the frozen group (14 vs. 16 days, respectively; P = 0.001), while no significant differences on platelet recovery were observed. Patients receiving frozen PBSC had a higher incidence of global acute graft‐versus‐host disease (aGVHD) (63 vs. 44%, P 
ISSN:0902-4441
1600-0609
DOI:10.1111/ejh.12140