Dendritic cells play a role in host susceptibility to Cryptosporidium parvum infection

Highlights • Depletion of DCs in vivo increases susceptibility to Cryptosporidium parvum infection. • Adoptive transfer of stimulated DCs reduces C. parvum infection levels. • Reduction in infection correlates to an increase in IFN-γ in T cell. • DCs pulsed with sporozoites and co-cultured with CD4+...

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Bibliographic Details
Published in:Immunology letters 2014-03, Vol.158 (1), p.42-51
Main Authors: Bedi, Brahmchetna, McNair, Nina N, Mead, Jan R
Format: Article
Language:English
Subjects:
Adoptive Transfer
Allergy and Immunology
Animals
CD11 Antigens - metabolism
CD11c-DTR-Tg
Cryptosporidiosis - immunology
Cryptosporidium
Cryptosporidium parvum - immunology
Cytokines - metabolism
Dendritic cells
Dendritic Cells - immunology
Dendritic Cells - transplantation
Diphtheria Toxoid - immunology
Disease Susceptibility
Humans
Innate response
Lymphocyte Activation - genetics
Mice
Mice, Inbred C57BL
Mice, Transgenic
Th1 Cells - immunology
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Summary:Highlights • Depletion of DCs in vivo increases susceptibility to Cryptosporidium parvum infection. • Adoptive transfer of stimulated DCs reduces C. parvum infection levels. • Reduction in infection correlates to an increase in IFN-γ in T cell. • DCs pulsed with sporozoites and co-cultured with CD4+ and CD8+ T cells produced higher IFN-γ levels.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2013.11.015